Over 500 References Supporting EDTA Chelation - Jace Medical ...

Over 500 References Supporting EDTA Chelation 

1. Toyota H, Shibata S (Kyoto University). Supplementary studies on pharmacology of disodium 

ethylenediaminetetraacetate (EDTA salt). Nippon Yakuriguku Zasshi. 1956;52:1-9. (CA51:11567e) 

2. Uhl HSM, Brown HH, Zlatkis A, Zak, B, Myers GB, Boyle AJ. Effect of ethylenediamine-tetraacetic 

acid (EDT) on cholesterol metabolism in man. Preliminary report of effect of parenteral and oral 

administration of disodium and calcium salts. Am J Clin Pathol. 1953; 23:1226-1233. (CA48:2257d) 

3. Vasil'eva OG. (Inst Ind Hyg Occup Dis, Acad Med Sci, USSR) Side effects of CaNa2 ethylenediaminetetraacetate 

in experimental lead intoxication. Gigiena 1 Sanitariya. 1961;26:22-5 (Mar.). (979) 

4. Vozar L. Complexons in food products and their effect on the metabolic processes. Prumysl potravin. 

1958; 9:649-653. (CA53:8461i) 

5. Vozar L. Effect of complexon III on the distribution of calcium and phosphorus in bones. Biologia. 

1958; 13:695-699. (CA55:5762e) 

6. Williams JD, Leigh DA. (Edgware General Hospital) Lead poisoning. Letters to the editor. British Med J. 

1964; 1:1511 (June 6). (2841) 

7. Williams JD, Matthews GA, Judd AW. (St. Paul's Hospital) Oral calcium disodium versenate in 

treatment of lead poisoning. British J Ind Med. 1962; 19-211-215 (July). (2491) 

8. Windsor E, Cronheim GE (Riker Labs, Inc.). Gastrointestinal absorption of heparin and synthetic 

heparinoids. Nature. 1961; 190:203-204. (CA55:23818a) [Heparin Na U.S.P. and the K salt of 

sulfopolyglucin can be absorbed from the gastrointestinal tract when given orally with an alk. salt of 

ethylenediaminetetraacetic acid (I). The chelation of Ca and (or) Mg ions by I may be involved.] 

9. Windsor E (to Riker Laboratories). Orally active therapeutic compositions, especially polysaccharide 

sulfates. U.S. 3,088,868 (Cl 167-55). May 7, 1963, Appl Aug. 18, 1958. (CA59:12598d) 

10. Wynn JE, Van't Riet B, Borzelleca JF (Med. Coll. of Virginia). Toxicity and pharmaco-dynamics of 

EGTA: oral administration to rats and comparisons with EDTA. Toxicol Appl Pharmacol. 1970; 16(3):807- 

817. (CA73) 

11. Yang SS. Toxicological investigations of ethylenediaminetetraacetic acid. Dissertation. Univ. Mass. 

1952:94 p. 

12. Rieders F, Copeland JE (Jefferson Med Coll). Inhibition of accumulation of chronically ingested lead in 

rats by simultaneous feeding of edathamil calcium disodium (Na2CaEDTA). Federation Proceedings. 1956; 

15:Abstract No. 1541 (Mar.). (693) 

13. Schuttmann C, Schuttmann W (Inst. Of Occup Med, Berlin-Lichtenberg). The medical prevention of 

occupational lead poisoning by oral administration of calciumdinatrium ethylenediaminetetraacetate. 

Zeitschrift fur Arztliche Fortbildung. 1963; 57:1301-1307 (Dec.). (2621) 

14. Shiels DO, Thomas DLG, Kearley E. Treatment of lead poisoning by edathamil calcium-disodium. 

AMA Arch of Ind Health. 1956; 13:489-498 (May). (1718) 

15. Savicevic M, Petrovic L. Prevention of industrial lead poisoning. Vojnosanitetski Pregled. 1962; 

19:531-535 (July-Aug.). (3191)

16. Salvini M (Univ. Padua). The calcium chelate of disodium ethylenediamine tetraacetate in the treatment 

of saturnism. Folia Medica (Naples). 1955; 38:2:111-126. (1616) 

17. Saruta N, Yamaguchi S. A new diagnostic method of occupational lead poisoning for group inspection. 

J Sci of Labour (Japan). 1957; 33:540 (July). (1855) 

18. Ritter J, Dacquet J (Inst. Hyg. Rabat, Morocco). Detection and ambulatory treatment of lead poisoning 

by oral administration of calcium di-sodium versenate. Maroc Medical. 1961; 40:377-382 (Apr.). (2323) 

19. Remy R (Inst. Physiol. Vet. Coll.). Experimental studies on lead poisoning in animals. I. Toxicology. II. 

Therapy and prophylaxis. Deutsche Tierurztliche Wochenschrift. 1956; 63:385-388; 405-408 (Oct. 1; 15). 

(692) 

20. Pott R. Control of lead exposure as practiced in a lead foundry. Zentralplatt fur Arbeltsmedizin 

Arbeitsschutz. 1961; 11:211-214 (Sept.). (2317) 

21. Pott R. Is prophylaxis of lead poisoning with EDTA possible? Archiv fur Gewerbe-pathologie 

Gewerbehygiene. 1959; 17:4:354-364. (2053) 

22. Pettinati L, Gribaudo C, Rasetti L. Oral and intravenous versenate in the therapy of chronic lesions 

caused by lead. Minerva Medica. 1962; 53:2092-2097 (July). (2458) 

23. Pendergrass JC. The effects of the chronic ingestion of low levels of inorganic mercury(11) and 

mercury(11) complexed with EDTA on the rodent neuronal cytoskeleton: possible role of these forms of 

environmental mercury exposure in the etiology of Alzheimer's disease. Diss Abstr Int B (Avail. Univ. 

Microfilms Int., Order No. DA9527428. 1975; 1995:56(4). (CA) 

24. Oser BL, Oser M, Spencer HC. Safety evaluation studies of calcium EDTA. Toxicol Appl Pharmacol. 

1963; 5:142-162. (CA59: 9223a) 

25. Moeschlin S. The clinical picture and therapy of lead poisoning. Zeitschrift fur Unfallmedizin 

Berufskrankheiten 51. 1958; 2:129-149. (1936) 

26. Myslak Z, Buczkowski M. The effect of calcium versenate (Ca-EDTA) on the kidney in the treatment 

of lead poisoning. Polskie Archiwum Medycyny Wewnetrznej. 1961; 31:853-856. (2304) [Kidney function 

tests (creatinine clearance, RN) were carried out on 20 out of 120 cases of chronic Pb poisoning treated by 

oral administration of CaEDTA. The results showed no harmful effect of EDTA on the kidneys during 

treatment.] 

27. Myslak Z. Treatment of chronic saturnism by oral administration of calcium versenate. Medycyna 

Pracy. 1960; 11:353-368. (2169) 

28. Nakaue HS, Thomas JM, Reid BL. Comparison of EDTA, terephthalic acid, sodium sulfate and acetylsalicylic 

acid as antibiotic potentiating agents in broiler chicks. Poultry Sci. 1967; 46:417-421. (NA38) 

29. Vozar L. Relation between peroral application of complexon 3 (ethylenediaminetetraacetic acid 

disodium salt) and the activity of alkaline phosphatase of blood serum. Biologia. 1960; 15:208-211. Z Inn 

Med. 1959; 14:676. (CA54:25290h) 

30. Thomsen MK, Jacobsen C, Skibsted L II. Mechanism of initiation of oxidation in mayonnaise enriched 

with fish oil as studied by electron spin resonance spectroscopy. Eur Food Res Technol. 2000; 211(6):381- 

386. (CA)

31. Sidbury JB Jr., Bynum JC, Fetz LL. (US Public Health Serv.) Effect of chelating agent on urinary lead 

excretion. Comparison of oral and intravenous administration. Proceedings of Soc Experimental Biol and 

Med. 1953; 82:226-228. (1444) 

32. McMahon FG. Comparison of the effect of Fe 3-specific (N, N-dihydroxyethylglycine), versenol, and 

calcium disodium versenate on urinary iron excretion in a patient with hemochromatosis. J Lab Clin Med. 

1956; 48:589-602. (CA51:3027c) 

33. McPhail AP, Patel RC, Bothwell TH, Lamparelli RD. EDTA and the absorption of iron from food. 

Amer J Clin Nutr. 1994; 59(3):644-648. (NA64) 

34. Manville IA, Moser R. Recent developments in the care of workers exposed to lead. The effect of the 

calcium chelate of disodium ethylenediamine-tetraacetic acid on led in the blood and urine of battery 

workers. AMA Arch Ind Health. 1955; 12:528-538 (Nov.). (1587) 

35. Heimbach J, Rieth S, Mohamedshah F, Slesinski R, Samuel-Fernando P, Sheehan T, Dickmann R, 

Borzelleca J. Safety assessment of iron EDTA (sodium iron (Fe3+) ethylenediaminetetraacetic acid): 

summary of toxicological, fortification and exposure data. Food Chem Toxicol. 2000; 38(1):99-111. (CA) 

[A review with many refs. Iron EDTA 

36. Davidsson L, Kastenmayer P, Hurrell RF. Sodium iron EDTA (NaFe(III)EDTA) as a food fortification: 

the effect on the absorption and retention of zinc and calcium in women. Amer J Clin Nutr. 1994; 

60(2):231-237. (NA64) 

37. Foreman H, Trujillo TT. Metabolism of carbon14-labeled ethylenediaminetetraacetic acid in human 

beings. J Lab Clin Med. 1954; 43:566-571. (CA48: 8949a) 

38. Foreman H. The pharmacology of some useful chelating agents. Metal Binding Med, Proc Symposium, 

Philadephia 1959. 1960; 82:94. (CA54:17719e) 

39. Bradley JE, Powell AM Jr. Oral calcium EDTA in lead intoxication of children. J Ped. 1954; 45:297- 

301 (Sept.). (2882) 

40. Capellaro F, Galdo PC, Alliod R. Possibility of treating saturnism by versenate by the oral route. 

Minerva Medica. 1963; 54:474-477. (2508) 

41. Calabrese A, Astolfi E, Mariani F. Oral treatment of lead intoxication with calcium versenate. Clinical 

and experimental study. Dia Medico. 1961; 33:2292-2294 (Oct. 5). (2239) 

42. Cotter LH. Treatment of lead poisoning by chelation. JAMA. 1954; 155:906-908. (CA52:10388a) 

43. Choie DD, Copley MP, Gindhart TD. Mitigation of intestinal cytotoxicity of cisplatin by EDTA in rats. 

Cancer Lett. 1983; 19(2):195-198. (CA) 

44. Cohn SH. The effect of chemical agents on the skeletal content and excretion of internally deposited 

fission products. US Atomic Energy Comm. ANL-5584. 1956; 144-149. (CA51:4557f) 

45. Flanagan PR, Chamberlain MJ, Valberg LS. The relationship between iron and lead absorption in 

humans. Am J Clin Nutr. 1982; 36(5):823-9. (CA) 

46. Forbes RM. Excretory patterns and bone deposition of zinc, calcium, and magnesium in the rat as 

influenced by zinc deficiency, EDTA, and lactose. J Nutr. 1961; 74:194-200. (CA59:7921b)

47. Davidson L, Almgren A, Hurrell RF. Sodium iron EDTA (NaFe(III) EDTA) as a food fortificant does 

not influence absorption and urinary excretion of manganese in healthy adults. J Nutr. 1998; 128(7): 1139- 

1143. (CA) 

48. Desoille H, Albahary C, Truhaut R, Boudene C. The lead mobilization test using CaNa2EDTA. XII 

Intern Cong Occup Health. Helsinki, Finland. 1957; Vol. 111, Proceedings, pp. 287-290. (1773) 

49. Davies NM, Jamali F. Pharmacological protection of NSAID-induced intestinal permeability in the rat: 

effect of tempo and metronidazole as potential free radical scavengers. Hum Exp Toxicol. 1997; 16(7):345- 

349. (CA) 

50. Kalz F, Quastel J II, Telner P, Schafer A, MacIntyre W. Changes in the electrophoretic patterns of the 

serums of psoriatics under various forms of therapy. J Invest Dermatol. 1958; 31:161-166. (CA53:20529a) 

51. Kehoe RA. Misuse of edathamil calcium-disodium for prophylaxis of lead poisoning. J Amer Med 

Assoc. 1955; 157:341-342 (Jan. 22). (1582) 

52. Mariani B, Bisetti A, Romeo V. Blood-cholesterol-lowering action of the sodium salt of 

calciumethylenediaminetetraacetic acid. Gazs Intern Med Chir. 1957; 62:1812-1823. (CA51:16953c) [Two 

g. daily of the drug, in 2 intravenous administrations, or (with a lower effect) by mouth or rectum, caused in 

humans a decrease of blood cholesterol, especially of its free fraction.] 

53. Stankovic M, Petrovic LJ, Poleti D (Inst. Public Health, Belgrade, Serbia). A contribution to the 

laboratory diagnostics of early saturnism. Arhiv za Higijenu Rada 1 Toksikologiju. 1962; 13:189-194. 

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54. Srbova J, Telsinger J (Clinic Occup. Dis., Prague). Absorption of calcium disodium salt of 

ethylenediaminetetraacetic acid after oral administration in the treatment of lead poisoning. Archiv fur 

Gewerbepatholgie und Gewerbehygiene 15. 1957; 6:572-580. (1858) 

55. Suenaka T, Kosaka H, Miyama K, Tabuchi T, Hirata M, Hara I, Masumoto D, Akaboshi S (Osaka 

Prefect Inst. Public Health, Osaka). The effects of repeated oral administration of calcium-EDTA on 

patients with chronic lead poisoning. Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei 

Hen. 1979; 17:1-9. (CA) 

56. Suenaka T, Miyajima K, Kosaka H, Tbuchi T, Hara I. Urinary excretion of heavy metals following oral 

administration of calcium EDTA. Osaka furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei Hen. 

1976; 14:19-23. (CA) 

57. Swenerton H, Hurley L S (Dept. Nutr. Univ. Calif., Davis, Calif.). Teratogenic effects of a chelating 

agent and their prevention by zinc. Science. 1971; 173 (3991), 62-64 (Eng). (CA75) 

58. Telsinger J, Srbova J. Effect of D-penicillinamine on the urinary excretion of mercury and lead. 

Pracovni Lekarstvi 16. 1964; 10:433-435. (2827) [Seven patients with chronic Pb poisoning were treated 

with daily oral doses of 150 mg D-penicillinamine for 4-7 days. Urinary excretion of Pb increased about 4fold 

which is practically as much as after administration of 0.5-g tablets of CaEDTA, 4 times/day. If future 

studies confirm its lower toxicity in long-term administration, D-penicillinamine may replace EDTA.] 

59. Tripod J. General pharmacodynamic aspects of mobilizing iron with chelators. Atti Acad Med 

Lombarda, Suppl 20. 1965; 2025-2027. (CA67) 

60. Tufft LS, Nockels CF. The effects of stress, escherichia coli, dietary ethylenediamine-tetraacetic acid, 

and their interaction of tissue trace elements in chicks. Poult. Sci. 1991; 70(12):2439-2449. (CA)

61. Tolot F, Jaquis GM, Soubrier R, Bresson JR. Lead mobilization in, and the &-aminolevulinic acid 

(ALA) content of the urine of lead-exposed subjects. Egesesegiudomany. 1966; 10(4):375-380. (CA66) 

62. Tolot F, Jaquis GM, Soubrier R, Bresson JR. The use of chelating agents "per os" in the treatment of 

prophylaxis of lead poisoning. Proceedings of the Society of Ind Med at Lyon. 1962; 23:376-379 (June). 

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63. Perrault M. Truhaut R, Klotz B, Boudene C, Dreux C, Clavel B, Chain F. The effectiveness of 

CaEDTA, in occupational lead poisoning. Archiv des Maladies Professionelles de Medecine du Travail et 

de Securite Sociale. 1956; 17:423-429; discussion 470-472. (1702) 

64. Mitchell Jr PH, Schroeder HA. Depression of cholesterol levels in human plasma following 

ethylenediamine tetracetate and hydralazine. J Chron Dis. 1955; 2:520-533. (CA54:18787i) 

65. Prasad T, Chhabra A, Atreja PP. Effect of feeding chelating agent (EDTA) on trace mineral balances in 

goats. Indian J Dairy Sci. 1994; 47(3):219-221. (CA) 

66. Rodriguez A. Substances that potentiate the absorption of vitamin B12 administered orally. Anales Inst. 

Farmacol. Espan. 1961; 9-10, 57-61. (CA61:2373a) 

67. Rotta C, Parigi A. Prevention of lead intoxication by oral administration of calcium versenate. Med del 

Lavoro. 1961; 52:769-779 (Dec.). (2325) 

68. Saita G, Moreo L. Lead and porphyrins in the bile of patients with lead poisoning treated with calcium 

versenate. Med del Lavoro. 1958; 49:376-384 (May). (1956) 

69. Scadding G, Bjarnason I, Brostoff J, Levi AJ, Peters TJ. Intestinal permeability to 51CR-labelled 

ethylenediaminetetraacetate in food-intolerant subjects. Digestion. 1989; 42(2):104-109. (NA59) 

70. Sidbury Jr JB. Lead poisoning, treatment with disodium calcium ethylenediamine-tetraacetate. Am J 

Med. 1955; 18:932-946 (June). (1622) 

71. Bersworth Chemical Co. The versenes for exacting chemical control of cations in solution. Technical 

Bulletin No. 2, 4th ed. 1952; 102 pp. (1313) 

72. Berti T. Pharmacological investigation on sodium bismuth ethylenediaminetetraacetate (Bi-EDTA). 

Arch Ital. Sci. Farmacol. 1956; 6:293-298. (CA51:9939h) 

73. British Industrial Biological Research Association. The metabolism of EDTA. Food and Cosmetics 

Toxicol. 1964; 2:741-745 (Dec.). (2670) 

74. Gervais MJ. The medical prevention of lead poisoning in an electrolytic zinc factory. Montpellier 

Medical. 1962; 61:12-27 (Jan.). (2401) 

75. Jugo S, Maljkovic T, Kostial K. Influence of chelating agents on the gastrointestinal absorption of lead. 

Toxicol. Appl. Pharmacol. 1975; 34(2):259-263. (CA) 

76. Teisinger J, Zumanova R, Zezula I. Effect of calcium salt of ethylenediaminetetraacetic acid on the 

binding of lead by erythrocytes and blood proteins. Pracovni lekufstvi. 1957; 9:277-280. (CA52:9447g) 

77. Stancev S. Prophylaxis of chronic lead poisoning by oral administration of CaNa2EDTA. First National 

Congress of Industrial Health. Abstracts of papers. 1963; 37-38. (2634)

78. Taucin EJ, Svilane ABV. Effect of EDTA and chlortetracycline on assimilation of trace elements by 

chickens. Fiziologiceski aktivnye komponenty pitanija zivotnyh. 1969; 163-170 Russian. (NA41) 

79. Suenaka T, Miyajima K, Kosaka H, Tabuchi T, Hara I. Urinary excretion of heavy metals following 

oral administration of calcium-EDTA. Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei 

Hen. 1977; 15:27-31. (CA) [Ca EDTA, administered to workers dealing with Pb, significantly increased Pb 

and Zn excretion in urine. There was a high correlation between urinary total metal and Zn concns.] 

80. Nishino S. Effect of oral administration of calcium ethylenediaminetetraacetate in lead poisoning. 

Kokumin Eisel. 1957; 26:90-95. (1834) 

81. Nottbohm L. The supervisory physician in plants presenting lead hazards. Medizinische Welt. 1963; 

44:224-228. (2596) 

82. Pagnotto LD, Elkins HB, Bayka I. Oral administration of edathamil calcium disodium (calcium 

disodium versenate). AMA Archives of Ind. Health. 1958; 17:29-33 (Jan.). (P1943) 

83. Parigi A, Rasetti L. Action of orally administered CaEDTA on the metabolism of the porphyrinic 

precursors in lead poisoning. Lavoro e Medicina 16. 1962; 3:44-50. (2452) 

84. Peters HA, Eichman PL, Price JM, Kozelka FL, Reese HH. Abnormal copper and trytophan 

metabolism and chelation therapy in anticonvulsant drug intolerance. Diseases Nervous System. 1966; 

27(2):97-107. (CA64:16509c) 

85. Petrovic LJ, Stankovic M, Savicevic M, Poleti D. Our experiences with calcium disodium edathamil. 

Proc. 13th Int. Congr. on Occup. Health July 25-29, 1960. 1961; pp 338-341. (2176) 

86. Pilat L, Moscovici B, Iorga M. CaNa2EDTA treatment in mercury intoxication. Proc. 13th Int. Congr. 

Occup. Health, 1960. 1961; p. 341-343. 

87. Prevot PA, Sulotto F, Poli G, Parigi A. Environmental lead pollution and the principal biological 

indexes for evaluating the risk of lead poisoning. Lav. Um. 1969; 21(5):200-209. (CA72) 

88. Reinl W. Prophylaxis of lead workers with orally administered Ca2EDTA. Zentralblatt fur 

Arbeitsmedizin und Arbeitsschutz. 1956; 6:5-8 (Jan.). (1709) 

89. Reinl W. Modern therapy of lead intoxication. Regensburger Jahrbuch fur Hrztliche Fortbildung. 

1959/60; 8:(8 pp). (2184) 

90. Roxburgh RC, Haas L. The diagnostic importance of glycosuria in lead poisoning in childhood. Arch 

Dis in Childhood. 1959; 34:70-73 (Feb.). (2957) 

91. Selander S. Treatment of lead poisoning. A comparison between the effects of sodium calcium-edetate 

and penicillamine administered orally and intravenously. Brit J Indust Med. 1967; 24:272-281. 

92. Bell RF, Gilliland JC, Boland JR, Sullivan BR. Effect of oral edathamil calcium-disodium on urinary 

and fecal lead excretion. Comparative excretory studies with intravenous therapy. AMA Arch Ind Health. 

1956; 13:366-371 (Apr.). (1642) 

93. Bersworth FC, Rubin M. Prophylactic calcium chelate compositions for heavy metal poisoning. U.S. 

Patent. 1959; 1,875,129 (Feb. 24), to Dow Chemical Co. From Chemical Abstracts 53:10672. (1982)

94. Bersworth FC, Rubin M. Organo-metallic detoxicants. U.S. Patent. 1955; 2,698,823 (Jan. 4) to F.C. 

Bersworth. From Chemical Abstracts 49:Abst. No. 4244. (1552) 

95. Bjarnason I, Peters TJ, Veall N. A persistent defect in intestinal permeability in coeliac disease 

demonstrated by 51Cr-labelled EDTA absorption test. Lancet. 1983; 1:323-325. 

96. Blomquist L, Bark T, Hedenborg G, Norman A. Evaluation of lactulose/mannitol and 51Crethylenediaminetetraacetic 

acid/14C-mannitol methods for intestinal permeability. Scand. J Gastro. 1997; 

32(6):805-812. (BA 104) 

97. Blumer W, Reich T. Leaded gasoline - A cause of cancer. Environment Int. 1980; 3:465-471. 

98. Blumer W. Calcium-disodium-EDTA treatment for cardiovascular symptoms. Plzen Lek Sborn Suppl. 

1990; 62:157-159. 

99. Cann HM, Verhulst HL. Edathamil calcium-sodium (EDTA) in lead poisoning. Tennessee Ind. Hygiene 

News 15. 1958; 1:3-4. (2936) 

100. Cho SS, Mejia L, Morel L, Samuel-Fernando P. Cooked cereal ingredient-containing products 

fortified with EDTA/iron compositions and methods for use. PCT Int. Appl. WO 99 05,920, 1999, US Appl. 

54,428 1997, 24 pp. (CA) 

101. Cowan TKJ, Phillips GD, Bragg DB. Effect of dietary EDTA on the ability of chicks to tolerate 

sodium chloride in the water. Canadian J Animal Sci. 1971; 51(3):633-637. (NA42) 

102. Engstroem B, Norin H, Jawait M, Ingman F. Influence of different cadmium-EDTA complexes on 

distribution and toxicity of cadmium in mice after oral or parenteral administration. Acta Pharmacol. 

Toxicol. 1980; 46(3):219-234. (CA) 

103. Gehres RF, Raymond S. A new chemical approach to the solution of urinary calculi. J Urol. 1951; 

65:474-483. (CA47:8241c) 

104. Greig JB. Sodium iron ethylenediamine tetraacetic acid (EDTA). WHO Food Addit. Serv. 2000; 

44:105-111 (Safety Evaluation of Certain Food Additives and Contaminants). (CA) A review with 9 refs. 

on toxicity of NaFeEDTA, including acute and short-term toxicity, genotoxicity, developmental toxicity 

and food and nutritional toxicity. 

105. Harishima S, Tsuchiya K, Kondo H, Motouchi M, Sakaguchi T, Mori A. Therapy and prevention of 

lead poisoning with calcium versenate. Keio J. Med. 7. 1958; 93-105. (1914) 

106. Hathcock JN, Hill CH, Matrone G. Vanadium toxicity and distribution in chicks and rats. J. Nutr. 

1964; 82(1):106-110. (CA60:12576g) 

107. Hurrell RF, Ribas S, Davidsson L. NaFe3+EDTA as a food fortificant: influence on zinc, calcium and 

copper metabolism in the rat. British J Nutr. 1994; 71(1):85-93. (NA64) 

108. Kojima S, Kiyozumi M, Matsumoto S, Yamamoto M, Nakamura C, Niho K. Studies on poisonous 

metals. III. Effects of chelating agents on gastrointestinal absorption, distribution, and excretion of 

cadmium chloride in rats. Eisei Kagaku. 1977; 23(1):43-47. (CA) 

109. Krari N, Allain P. Effects of three chelating agents, EDTA, NTA, and TPP, on the concentration of 

elements in rat tissues. Biol. Trace Elem. Res. 1991; 29(2):125-131. (CA)

110. Makashev KK. Effect of calcium and disodium salts of ethylenediaminetetraacetic acid on lead 

absorption, accumulation, and excretion from the system after lead intoxication. Trudy Inst Kraevol 

Patologil, Akademiya Nauk Kazakhskoi SSR. 1962; 10:180-189. (1008) 

111. Madsen JL, Scharff O, Rabol A, Krogsgaard OW. Relationship between small-intestinal transit rate 

and intestinal absorption of 14C-labelled mannitol and 51Cr-labelled ethylenediamine-tetraacetic acid in 

healthy subjects. Scand. J Gastro. 1996; 31(3):254-259. (NA66) 

112. MacPhail AP, Bothwell TH, Torrance JD, Derman DP, Bezwoda WR, Charlton RW, Mayet F. Factors 

affecting the absorption of iron from Fe(III)EDTA. British J Nutr. 1981; 45(2):25-227. (NA52) 

113. Merville R, Dequidt J, Fontaine G. Ambulatory treatment of occupational lead poisoning by calcium 

disodium edetic acid. Lille Med. 4. 1959; 5:291-293. (2035) 

114. Stankovic M, Petrovic LJ, Poleti D. Application of Ca2EDTA (dicalcium ethylenediaminetetraacetate) 

for the diagnosis of lead poisoning. Acta Pharm. Jugoslav. 1960; 10:155-159. (2202) The 

compound was administered orally to 24 printers, 18 persons with severe Pb poisoning, and 8 controls with 

no Pb exposure. The upper limit of Pb excretion in urine after 3 g CaEDTA was 0.340 mg/24 hr. 

115. Suso FA, Edwards Jr HM. Influence of various chelating agents on absorption of cobalt-60, iron-59, 

manganese-54, and zinc-65 by chickens. Poultry Sci. 1968; 47(5):1417-1425. (CA70) 

116. Vozar L. The action of complexon 3 on the copper balance and level in the organism after oral 

administration. J'harmazie. 1959; 14:459-466. (CA54:7892d) 

117. Nielsen FH, Sunde ML, Hockstra WG. Effect of some dietary synthetic and natural chelating agents 

on the zinc-deficiency syndrome in the chick. J Nutr. 1966; 89(1):35-42. (CA65:14176h) 

118. Pedinelli M, Stringari M. Observations on the treatment "per os" with chelating agents in tetraethyl 

lead production workers. Rassegna di Medicina Industriale. 1959; 28:514-525 (Nov.-Dec.) (2048) 

119. Preda N, Niculescu T, Rafaila E. The treatment of lead intoxication with chelating agents. Igiena 

(Bucharest)13. 1964; 3:233-242. (2784) Treatment of Pb-poisoned patients in the Clinic for Occupational 

Diseases, Bucharest, with iv injections of 2 g CaNa2EDTA/day for 2-20 days markedly increased urinary 

excretion of Pb. Oral doses of 4-6 g EDTA/day were less effective. 

120. Sapeika N. Actions of lead ethylenediaminetetraacetic acid (EDTA) complex. Arch. Intern. 

Pharmacodynamie. 1955; 101:488-494. (CA49:14168e) 

121. Savicevic M, Petrovic LJ. New views on the treatment of occupational lead poisoning. Vojnosanitetski 

Pregled. 1964; 21:173-177. (2804) 

122. Svicevic M, Petrovic L, Stankovic M, Djordjevic S. Experiences with CaNa2EDTA (mosatil bayer) in 

chronic Pb exposure. Zentralblatt fur Arbeitsmedizin und Arbeitsschutz. 1959; 9:6-12 (Jan.) (2062) 

123. Rubin M. Design of chelates for therapeutic objectives. Fed. Proceed. 20, Suppl. 10. 1961; 2:149-157 

(Sept.) (2327) 

124. Rosenman RH, Smith MK. The effect of certain chelating substances, salts of ethylenediaminetetraacetic 

acid (EDTA), upon cholesterol metabolism in the rat. J Clin. Invest. 1956; 35:11-19. 

(CA50:6676b)

125. Roldan M, Suarez CL, Perdomo GM, Camarero SC, Escobar CH. Study of intestinal permeability in 

celiac disease with 51 Cr-EDTA. Acta Gastroenterol Latinoam. 1994; 24:37-40. 

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219. Anon. Calcium disodium ethylenediaminetetraacetate: permitted addition to certain foods. Federal 

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220. Anon. Black-eye peas, potatoes: order listing disodium EDTA and calcium disodium EDTA as 

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221. Anon. The complexities of EDTA. Food Cosmet. Toxicol. 1972; 10:697-700. 

222. Anon. Disodium EDTA (Disodium ethylenediaminetetraacetate). Federal Register, cf. CA 57, 12964d. 

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223. Anon. Dressings for foods. Food additives. Calcium disodium ethylenediamine-tetraacetate, disodium 

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224. Anon. Food additives. Boiler water additives. Federal Register, cf. CA 58, 10661b. Oct. 16, 1964; 

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225. Anon. Food additives. Adhesives. Federal Register, CF. ca 59, 13261c. Dec. 31, 1963; 28:14493. 

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226. Anon. Food additives. Calcium disodium EDTA. Federal Register, cf. CA 62, 3316c. May 21, 1965; 

30:6915-6916. (CA63:6236e) [The previous regulation under the Federal Food, Drug, and Cosmetic Act 

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227. Anon. Food additives. Calcium disodium EDTA. Federal Register, cf. CA 55. August 29, 1961; 

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228. Anon. Food additives. Calcium disodium ethylenediaminetetraacetate. Federal Register, cf. CA 55, 

4811c. Apr. 4, 1961; 26:2780. (CA55:10737c) [The previous regulations under the Food, Drug, and 

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229. Anon. Food additives. Calcium disodium EDTA. Federal Register, cf. CA 66:94047h. May 2, 1967; 

32:6686. (CA67) [The title compd. may be used under the Federal Food, Drug and Cosmetic Act at a max. 

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230. Anon. food additives. Calcium disodium ethylenediaminetetraacetate. Federal Register, cf. CA 55, 

10737c. July 13, 1961; 26:6271-6272. (CA55:20243a) 

231. Anon. Food additives. Chelating agents. Federal Register, cf. CA 55, 20246a. Jan. 12, 1962; 27:339. 

(CA56:7755e) [Di-Na ethylenediaminetetraacetate is included under the Fed. Food, Drug, and Cosmetic 

Act as a chelating agent in the list of substances that may be used in the manuf. of paper and paperboard 

that contacts food.] 

232. Anon. Food additives. Calcium disodium EDTA (calcium disodium ethylenediaminetetraacetate; 

calcium disodium (ethylenedinitrilo)tetraacetate). Federal Register, cf. CA 58, 3822b. Sept. 25, 1963; 

28:10377-10378. (CA59:14495e) [The title compd. may be used as a stabilizer of the color of canned clams 

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233. Anon. Food additives. Disodium EDTA. Federal Register, cf. CA 62, 3316c. Nov. 25, 1964; 29:15814. 

(CA62:7027h) [A max. of 500 ppm. di-Na EDTA may be used under the Federal Food, Drug, and 

Cosmetic Act in canned strawberry pie filling to promote color retention.] 

234. Anon. Food additives. Disodium EDTA (Disodium ethylenediaminetetraacetate). Federal Register, cf. 

CA 56, 12040a. Aug. 23, 1962; 27:8424. (CA57:12964d) [A max. of 165 p.p.m. di-Na EDTA may be used 

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235. Anon. Food additives. Disodium EDTA. Federal Register, cf. CA 60, 13801c. Aug. 28, 1964; 

29:12364-12365. (CA61:12544d) [The previous regulation under the Federal Food, Drug, and Cosmetic 

Act is revised to permit the use of di-Na EDTA to promote color retention in dried banana products (315 

p.p.m. max.) used as a component of cereal products and in canned cooked chickpeas (165 p.p.m. max.).] 

236. Anon. Food additives. Disodium EDTA. Federal Register. June 18, 1965; 30:7895. (CA63:6238b) 

[Disodium EDTA, min. 99% dihydrate, may be used under the Federal Food, Drug, and Cosmetic Act as a 

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237. Anon. Food additives. Disodium EDTA. Federal Register, cf. CA 71:100539s. Jun 10, 

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238. Anon. Food additives. Disodium EDTA. Federal Register, cf. CA 67:2133c. Aug 14, 1969; 

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239. Anon. Food additives. Disodium EDTA. Federal Register, cf. CA 62:7027h. April 25, 1967; 32:6393. 

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240. Anon. Food additives. Disodium EDTA. Federal Register, cf. CA 63:6238b. Nov 6, 1968; 

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241. Anon. Food additives. Disodium EDTA (disodium ethylenediaminetetraacetate). Federal Register, cf. 

CA 55, 20243a. Jan. 31, 1962; 27:883. (CA56:12040a) [A tolerance of 150 p.p.m. of the title compd. is 

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500. Schmidt P. Nutritional and hematological disturbances in rats after gastrectomy in rats. Kiserl. 

Orvostud. 1974; 26(6):655-664. (CA82) 

501. Schroeder HA, moderator. Discussion. In: Metal-Binding in Medicine by MJ Seven and LA Johnson, 

Ed., JB Lippincott Co., Phila. 1960; p. 154-159. 

502. Schroeder HA. A practical method for the reduction of plasma cholesterol in man. Chron. Dis. 1956; 

4:461-468. 

503. Seeberg VP, Hidalgo J, Wilken W. Hemoglobin regeneration following oral administration of chelated 

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504. Shibata S. Toxicological studies of EDTA salt (disodium ethylenediaminetetraacetate). Nippon 

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505. Shaw JH, Gupta OP. The relation of a chelating agent to smooth-surface lesions in the white rat. J 

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506. Shapiro R. Chelates in contrast roentgenography. In: Metal-Binding in Medicine, by MJ Seven and 

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Gordon Research Institute / Reference Material

Over 500 References Supporting EDTA Chelation - Jace Medical ...

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