Publication list of Prof. Dr. Rolf Müller - Helmholtz-Zentrum für ...

Publication list 

I. Original papers in peer reviewed journals 

177. Kaufmann, K., Simmons, L., Herrmann, J., Schwär, G., Luniak, N., and Müller, R. (2012) 

Activity-guided screening of bioactive natural compounds implementing a new glucocorticoidreceptor-translocation 

assay and detection of new anti-inflammatory steroids from bacteria, 

Biotechnology Letters, in press. 

176. Katsuyama, Y., Harmrolfs, K., Pistorius, D., Li, Y., and Müller, R. (2012) A semipinacol 

rearrangement directed by an enzymatic system featuring dual-function FAD-dependent 

monooxygenase, Angewandte Chemie-International Edition in English, 51,(37), 9437- 

9440. 

175. Rath, S., Liebl, J., Fürst, R., Ullrich, A., Burkhart, J.L., Kazmaier, U., Herrmann, J., Müller, 

R., Günther, M., Schreiner, L., Wagner, E., Vollmar, A.M., and Zahler, S. (2012) Antiangiogenic 

effects of the tubulysin precursor pretubulysin and of simplified pretubulysin 

derivatives, British Journal of Pharmacology, in press, doi: 10.1111/j.1476- 

5381.2012.02037.x. 

174. Wischang, D., Radlow, M., Schulz, H., Vilter, H., Viehweger, L., Altmeyer, M.O., Kegler, C., 

Herrmann, J., Müller, R., Gaillard, F., Delage, L., Leblanc, C., and Hartung, J. (2012) 

Molecular cloning, structure, and reactivity of the second bromoperoxidase from Ascophyllum 

nodosum, Bioorganic Chemistry, in press. 

173. Bian, X., Plaza, A., Zhang, Y., and Müller, R. (2012) Luminmycins A-C, cryptic natural 

products from Photorhabdus luminescens identified by heterologous expression in 

Escherichia coli, Journal Of Natural Products, in press. 

172. Klein, T., Henn, C., de Jong, J.C., Zimmer, C., Kirsch, B., Maurer, C.K., Pistorius, D., Müller, 

R., Steinbach, A., and Hartmann, R.W. (2012) Identification of small-molecule antagonists of 

the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit 

discovery and optimization, ACS Chemical Biology, in press. 

171. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A., and Müller, R. (2012) Leopolic acid 

A, isolated from a terrestrial actinomycete, Streptomyces sp, Tetrahedron Letters, in press. 

170. Herrmann, J., Elnakady, Y.A., Wiedmann, R.M., Ullrich, A., Rohde, M., Kazmaier, U., 

Vollmar, A.M., and Müller, R. (2012) Pretubulysin: From hypothetical biosynthetic 

intermediate to potential lead in tumor therapy, PLoS ONE, 7,(5), e37416. 

169. Plaza, A., Garcia, R., Bifulco, G., Martinez, J.P., Huttel, S., Sasse, F., Meyerhans, A., 

Stadler, M., and Müller, R. (2012) Aetheramides A and B, potent HIV-inhibitory 

depsipeptides from a myxobacterium of the new genus "Aetherobacter", Organic Letters, 

14,(11), 2854-2857. 

168. Bian, X., Huang, F., Stewart, F.A., Xia, L., Zhang, Y., and Müller, R. (2012) Direct cloning, 

genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster 

in E. coli through Red/ET recombineering, ChemBioChem, 13,(13), 1946-1952. 

167. Ruge, C.A., Schaefer, U.F., Herrmann, J., Kirch, J., Cañadas, O., Echaide, M., Pérez-Gil, J., 

Casals, C., Müller, R., and Lehr, C.M. (2012) The interplay of lung surfactant proteins and 

lipids assimilates the macrophage clearance of nanoparticles, PLoS ONE, 7,(7), e40775. 

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166. Mohr, K.I., Garcia, R.O., Gerth, K., Irschik, H., and Müller, R. (2012) Sandaracinus 

amylolyticus gen. nov., sp. nov., a starch degrading soil myxobacterium and the description 

of Sandaracinaceae fam. nov., International Journal of Systematic and Evolutionary 

Microbiology, 62,(Pt 5), 1191-1198. 

165. Hüttel, S., Müller, R. (2012) Methods to optimize myxobacterial fermentations using off-gas 

analysis, Microbial Cell Factories, 11,(1), 59. 

164. Steinmetz, H., Zander, W., Shushni, M.A., Jansen, G., Dehn, R., Dräger, G., Kirschning, A., 

and Müller, R. (2012) Precursor-directed syntheses and biological evaluation of new 

elansolid derivatives, ChemBioChem, 13,(12), 1813-1817. 

163. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A., and Müller, R. (2012) Pimprinols A– 

C, from the terrestrial actinomycete, Streptomyces sp., Tetrahedron Letters, 53,(24) 3009- 

3011. 

162. Jahns, C., Hoffmann, T, Müller, S., Gerth, K., Washausen, P., Höfle, G., Reichenbach, H., 

Kalesse, M., and Müller, R. (2012) Pellasoren: Struktur, Biosynthese und Totalsynthese 

eines zytotoxischen Sekundärmetaboliten aus Sorangium cellulosum. Angewandte Chemie, 

doi: 10.1002/ange.201200327. 

161. Fu, J., Bian, X., Hu, S., Wang, H., Huang, F., Seibert, P. M., Plaza, A., Xia, L., Müller, R.*, 

Stewart, A. F.*, and Zhang, Y.*(2012) Full-lenght RecE enhances linear-linear homologous 

recombination and facilitates direct cloning and bioprospecting, Nature Biotechnology, 30, 

440-446. 

* Corresponding authors 

160. Quade,N., Huo,L., Rachid,S., Heinz,D.W. and Müller,R. (2012) Unusual carbon fixation 

giving rise to diverse polyketide extender units, Nat Chem Biol., 8 (1), 117-124. 

159. Cortina,N.S., Krug,D., Plaza,A., Revermann,O. and Müller,R. (2012) Myxoprincomid: a 

natural product from Myxococcus xanthus discovered by comprehensive analysis of the 

secondary metabolome, Angew. Chem. Int. Ed., 51 (3), 811-816. 

158. Barbier,J., Jansen,R., Irschik,H., Benson,S., Gerth,K., Böhlensorf,B., Höfle,G., 

Reichenbach,H., Wegner,J., Zeilinger,C., Kirschning,A. and Müller,R. (2012) Isolation and 

total synthesis of icumazoles and noricumazoles - antifungal antibiotics and cation-channel 

blockers from Sorangium cellulosum, Angew. Chem. Int. Ed., 51 (5), 1256-1260. 

157. Zander,W., Irschik,H., Augustiniak,H., Herrmann,M., Jansen,R., Steinmetz,H., Gerth,K., 

Kessler,W., Kalesse,M., Höfle,G. and Müller,R. (2012) Sulfangolids, macrolide sulfate esters 

from Sorangium cellulosum, Chemistry - A European Journal, 18 (20), 6264-6271. 

156. Mohr,K.I., Garcia,R.O., Gerth,K., Irschik,H. and Müller,R. (2012) Sandaracinus amylolyticus 

gen. nov., sp. nov., a starch degrading soil myxobacterium and the description of 

Sandaracinaceae fam. nov., Int. J. Syst. Evol. Microbiol.,62, 1191-1998. 

155. Pistorius,D., Müller,R. (2012) Discovery of the rhizopodin biosynthetic gene cluster in 

Stigmatella aurantiaca Sg a15 by genome mining, ChemBioChem, 13 (3), 416-426. 

154. Xiao,Y., Gerth,K., Müller,R. and Wall,D. (2012) Myxobacteria antibiotic TA (myxovirescin) 

inhibits type II signal peptidase, Antimicrobial Agents Chemotherapy, 56 (4), 2014-2021. 

153. Chai,Y.; Shan,S.; Weissman,K.J.; Hu,S.; Zhang,Y.; Müller,R. (2012) Heterologous 

Expression and genetic engineering of the tubulysin biosynthetic gene cluster using red/ET 

recombineering and inactivation mutagenesis, Chemistry & Biology, 19 (3), 361-371. 

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152. Gawas,D., Garcia,R., Huch,V. and Müller,R. (2011) A highly conjugated dihydroxylated C-28 

steroid from a myxobacterium, J. Nat. Prod., 74 (5), 1281-1283. 

151. Burkhart,J.L., Müller,R. and Kazmaier,U. (2011) Syntheses and evaluation of simplified 

pretubulysin analogues, Eur. J. Org. Chem., 2011 (16), 3050-3059. 

150. Khatri,Y., Hannemann,F., Perlova,O., Müller,R. and Bernhardt,R. (2011) Investigation of 

cytochromes P450 in myxobacteria: excavation of cytochromes P450 from the genome of 

Sorangium cellulosum So ce56, FEBS Lett., 585 (11), 1506-1513. 

149. Proschak,A., Schultz,K., Herrmann,J., Dowling,A.J., Brachmann,A.O., ffrench-Constant,R., 

Müller,R. and Bode,H.B. (2011) Cytotoxic Fatty Acid Amides from Xenorhabdus, 

ChemBioChem, 12 (13), 2011-2015. 

148. Pistorius,D., Li,Y., Mann,S. and Müller,R. (2011) Unprecedented anthranilate priming 

involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis, J. Am. 

Chem. Soc., 133 (32), 12362-12365. 

147. Pistorius,D., Li,Y., Sandmann,A., Weissman,K.J. and Müller,R. (2011) Completing the 

puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15, Molecular Biosystems, 

133 (32), 12362-12365. 

146. Stec,E., Pistorius,D., Müller,R. and Li,S.M. (2011) AuaA, a membrane-bound 

farnesyltransferase from Stigmatella aurantiaca, catalyzes the prenylation of 2-methyl-4hydroxyquinoline 

in the biosynthesis of aurachins, ChemBioChem, 12 (11), 1724-1730. 

145. Simmons,L.; Kaufmann,K.; Garcia,R.; Schwaer,G.; Huch,V.; Müller,R., (2011) Bendigoles D- 

F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009, 

Bioorganic & Medicinal Chemistry, 19 (22), 6570-6575. 

144. Cortina,N.S., Revermann,O., Krug,D. and Müller, R. (2011) Identification and 

characterization of the althiomycin biosynthetic gene cluster in Myxococcus xanthus DK897. 

ChemBioChem., 12 (9), 1411-1416. 

143. Pereira, A. R., Etzbach, L., Engene, N., Müller, R., & Gerwick, W. H. (2011) Molluscicidal 

Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria. Journal Of Natural 

Products, (74 (5), 1175-1181. 

142. Kopp, M., Irschik, H., Gemperlein, K., Buntin, K., Meiser, P., Weissman, K. J., Bode, H. B., 

Müller, R. (2011). Insights into the complex biosynthesis of the leupyrrins in Sorangium 

cellulosum So ce690. Molecular Biosystems, 7 (5), 1549-1563. 

141. Jansen, R.,Gerth, K., Steinmetz, H.,Reinecke, S., Kessler, W., Kirschning, A., Müller, R. 

(2011) Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti 

Chemistry - A European Journal, 17(28), 7739-7744. 

140. Garcia, R., Pistorius, D., Stadler,M., Müller, R. (2011) Fatty acid Related Phylogeny of 

Myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids Journal of 

Bacteriology, 193 (8):1930–1942. 

139. Okanya, P., Mohr, K., Gerth, K., Jansen, R. Müller, R. (2011) Marinoquinolines A – F, 

pyrroloquinolines from the bacterium Ohtaekwangia kribbensis (bacteroidetes) Journal of 

Natural Products, 74 (4), 603-608. 

138. Zander, W.,Gerth, K., Mohr, K.I., Kessler, W., Jansen, R., Müller, R. (2011). Roimatacene, 

an antibiotic against gram-negative bacteria isolated from Cystobacter ferrugineus Cb G35 

(myxobacteria) Chem. Eur. J., 17 /28), 7875-7881. 

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137. Rachid, S., Huo, L.,Herrmann, J.,Stadler, M., Köpcke, B., Bitzer, J., Müller, R. (2011), Mining 

the cinnabaramide biosynhetic pathway to generate novel proteasome inhibitors. 

ChemBioChem, 12 (6), 922-931. 

136. Garcia, R., Pistorius, D., Stadler, M., Müller, R. (2011) Chemo-phylogeny of myxobacteria 

and discovery of PUFAs. Journal of Bacteriology, 193 (8), 1930-1942. 

135. Huntley, S., Hamann, N., Wegener-Feldbrügge, S., Treuner-Lange, A., Kube, M., Reinhardt, 

R., Klages, S., Müller, R., Ronning, C.M., Nierman, W.C., Søgaard-Andersen, L. (2011) 

Comparative genomic analysis of fruiting body formation in myxococcales. Molecular 

Biology and Evolution, 28 (2): 1083-1097. 

134. Pistorius, D., Ullrich, A., Lucas, S., Hartmann, R. W., Kazmaier, U., Müller, R. (2011) 

Biosynthesis of 2-alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for 

therapeutic interference with pathogenicity. ChemBioChem, 12 (6), 850-853. 

133. Dehn, R.*, Katsuyama, Y.*, Weber, A., Gerth, K., Jansen, R., Steinmetz, H., Höfle, G., 

Müller, R.**, Kirschning, A.** (2011) Molecular basis of elansolid biosynthesis: evidence for 

an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition / 

macrolactonization. Angewandte Chemie Int. Ed., 50 (17): 3968-3973. 

* These authors contributed equally to this work 

** Corresponding authors 

132. Steinmetz,H., Gerth,K., Jansen,R., Schläger,N., Dehn,R., Reinecke,S., Kirschning,A., and 

Müller,R. (2011). Elansolid A, a unique macrolide antibiotic from chitinophaga sancti isolated 

as two stable atropisomers. Angew. Chem. Int. Ed. 50, 532-536. 

131. Khatri, Y., Hannemann, F., Ewen, K.M., Pistorius, D., Perlova, O., Kagawa, N., Brachmann, 

A.O., Müller, R., Bernhard, R. (2010) The CYPome of Sorangium cellulosum So ce56 and 

identification of CYP109D1 as a new fatty acid hydroxylase, Chemistry & Biology, 17(12): 

1295-1305. 

130. Nawrath, T., Gerth, K., Müller, R., Schulz,S. (2010) Volatile Methyl Esters of Medium Chain 

Length from the Bacterium Chitinophaga Fx7914, Chemistry & Biodiversity, 7, 2228-2253. 

129. Brodmann, T., Janssen, D., Sasse, F., Irschik, H., Jansen, R., Müller, R., Kalesse, M. (2010) 

Isolation and Synthesis of Chivotriene, a Chivosazole Shunt Product from Sorangium 

cellulosum, Eur. J. Org. Chem., 2010 (27): 5155-5159. 

128. Binz, T.M., Maffioli, S.I., Sosio, M., Donadio, S., Müller, R. (2010) Insights into an unusual 

Nonribosomal Peptide Synthetase Biosynthesis: The Identification and Characterization of 

the GE81112 Biosynthetic Gene Cluster, Journal of Biological Chemistry, 285, 32701- 

32719. 

127. Garcia, R., Gerth, K., Stadler, M., Dogma Jr., I.J., Müller, R., (2010) Expanded phylogeny of 

myxobacteria and evidence for cultivation of the 'unculturables', Molecular Phylogenetics 

and Evolution, 57(2): 878-887. 

126. Irschik, H., Kopp, M., Weissman, K.J., Buntin, K., Piel, J., Müller, R. (2010) Analysis of the 

sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic 

analysis for deciphering natural product assembly by trans-AT PKS, ChemBioChem, 11 

(13):1840-1849. 

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125. Daum, M., Schnell, H.J., Herrmann, S., Günther, A., Murillo, R., Müller, R., Bisel, P., Müller, 

M., Bechthold, A. (2010) Functions of Genes and Enzymes Involved in Phenalinolactone 

Biosynthesis, ChemBioChem, 11 (10): 1383-1391. 

124. Nawrath, T., Gerth, K., Müller, R., Schulz, S.(2010) The biosynthesis of the aroma volatile 2methyltetrahydrothiophen-3-one 

in the bacterium Chitinophaga Fx7914, ChemBioChem, 11 

(13):1914-1919. 

123. Erol, Ö., Schäberle, T.F., Schmitz, A., Rachid, S., Gurgui, C., El Omari, M., Lohr, F., 

Kehraus, S., Piel, J., Müller, R., König, G.M. (2010) Biosynthesis of the myxobacterial 

antibiotic corallopyronin A. ChemBioChem, 11(9): 1253-1265. 

122. Buntin, K., Weissman, K.J., Müller, R. (2010) An unusual thioesterase promotes 

isochromanone ring formation in ajudazol biosynthesis. ChemBioChem, 11 (8): 1137-1146. 

121. Li, Y., Weissman, K.J., Müller, R. (2010) Insights into multienzyme docking in hybrid PKS- 

NRPS megasynthetases revealed by heterologous expression and genetic engineering. 

ChemBioChem, 11(8): 1069-1075. 

120. Buntin, K., Irschik, H., Weissman, K.J., Luxenburger, E., Blöcker, H., Müller, R. (2010) 

Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for 

natural product structural diversity. Chemistry & Biology, 17 (4): 342-356. 

119. Rachid, S., Revermann, O., Dauth, C., Kazmaier, U., Müller, R. (2010) Characterization of a 

novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of 

chondrochloren from an acylated tyrosine. Journal of Biological Chemistry, 285 (17): 

12482-12489. 

118. Chai, Y., Pistorius, D., Ullrich, A., Weissman, K.J., Kazmaier, U., Müller R. (2010) Discovery 

of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004. 

Chemistry & Biology, 17 (3): 296-309. 

117. Jansen, R., Irschik, H., Huch, V., Schummer, D., Steinmetz, H., Bock, M., Schmidt, T. 

Kirschning, A., Müller, R. (2010) Carolacton - a Macrolide Ketocarbonic Acid Reducing 

Biofilm Formation by the Caries- and Endocarditis-associated Bacterium Streptococcus 

mutans. European Journal of Organic Chemistry, 2010 (7): 1284-1289. 

116. Bindl, M., Ludovic, J., Herrmann, J., Müller, R., Fürstner, A. (2009) Preparation, modification, 

and evaluation of cruentaren A and analogues. Chemistry. A European Journal, 15 (45): 

12310-12319. 

115. Ullrich, A., Herrmann, J., Müller, R., Kazmaier, U. (2009) Synthesis and Biological 

Evaluation of Pretubulysin and Derivatives. European Journal of Organic Chemistry, 2009 

(36): 6367-6378. 

114. Ewen, K. M., Hannemann, F., Khatri, Y., Perlova, O., Kappl, R., Krug, D., Hüttermann, J., 

Müller, R., Bernhardt, R. (2009) Genome mining in Sorangium Cellulosum SO CE56 – 

Identification and Characterization of the homologous electron transfer proteins of a 

myxobacterial cytochrome P450, Journal of Biological Chemistry, 284 (42): 28590-28598. 

113. Nagano, T., Pospíšil, J., Chollet, G., Schulthoff, S., Hickmann, V., Moulin, E., Herrmann, J., 

Müller, R., Fürstner, A. (2009) Total Synthesis and Biological Evaluation of the Cytotoxic 

Resin Glycosides Ipomoeassin A–F and Analogues, Chemistry – A European Journal, 15 

(38): 9697-9706. 

112. Bertsch, A., Leinenbach, A., Pervukhin, A., Lubeck, M., Hartmer, R., Baessmann, C., 

Elnakady, Y. A., Müller, R., Böcker, S., Huber, C. G., Kohlbacher O. (2009) De novo peptide 

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sequencing by tandem MS using complementary CID and electron transfer dissociation, 

Electrophoresis, 30 (21):3736-3747. 

111. Leinenbach A., Hartmer R., Lubeck M., Kneissl B., Elnakady Y.A., Baessmann C., Müller R., 

Huber C.G. (2009) Proteome analysis of Sorangium cellulosum employing 2D-HPLC-MS/MS 

and improved database searching strategies for CID and ETD fragment spectra, Journal of 

Proteome Research, 8: 4350-4361. 

110. Ullrich, A., Chai, Y., Pistorius, D., Elnakady, Y. A., Herrmann, J. E., Weissman, K. J., 

Kazmaier, U., Müller, R. (2009) Pretubulysin, a potent and chemically-accessible tubulysin 

precursor from Angiococcus disciformis, Angew Chem Int Ed, 48 (24): 4422-4425. 

109. Krug, D., Müller, R. (2009) Discovery of Additional Members of the Tyrosine Aminomutase 

Enzyme Family and the Mutational Analysis of CmdF, ChemBioChem, 10 (4): 741-750. 

108. Buedenbender, S., Rachid, S., Müller, R., Schulz, G. E. (2009) Structure and action of the 

myxobacterial chondrochloren halogenase CndH: A new variant of FAD-dependent 

halogenases, J. Mol. Biol., 385 (2): 520-530. 

107. Rachid, S., Scharfe, M., Blöcker, H., Weissman, K. J., Müller, R. (2009) Unusual Chemistry 

in the Biosynthesis of the Antibiotic Chondrochlorens, Chemistry & Biology, 16 (1): 70-81. 

106. Perlova, O., Gerth, K., Kuhlmann, S., Zhang, Y., Müller, R. (2009) Novel expression hosts 

for complex secondary metabolite megasynthetases: Production of myxochromide in the 

thermopilic isolate Corallococcus macrosporus GT-2, Microbial Cell Factories, 8 (1). 

105. Rachid, S., Gerth, K., Müller, R. (2009) NtcA – A negative regulator of secondary metabolite 

biosynthesis in Sorangium cellulosum, J. Biotech., 140 (1-2): 135-142. 

104. Bolten, C. J., Heinzle, E., Müller, R., Wittmann, C. (2009) Investigation of the central carbon 

metabolism of Sorangium cellulosum: Metabolic network reconstruction and quantification of 

pathway fluxes. J Microbiol Biotechnol, 19 (1): 23-36. 

103. Garcia, R. O., Reichenbach, H., Ring, M. W., Müller, R. (2009) Phaselicystis flava gen., nov., 

sp. nov., an arachidonic acid-containing soil myxobacterium, and the description of 

Phaselicystidaceae fam. nov., International Journal of Systematic and Evolutionary 

Microbiology, 59 (Pt6): 1524-1530. 

102. Bode, H. B., Ring, M. W., Schwär, G., Altmeyer, M. O., Kegler, C., Jose, I. R., Singer, M., 

Müller, R. (2009) Identification of additional players in the alternative biosynthesis pathway 

to isovaleryl-CoA in the myxobacterium Myxococcus xanthus, ChemBioChem, 10 (1): 128- 

140. 

101. Zöllner, A., Dragan C.-A., Pistorius, D., Müller, R., Bode, H.B., Peters, F.T., Maurer, H. H., 

Bureik, M. (2009) Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and 

myristic acid, Biological Chemistry, 390 (4): 313-317. 

100. Jansen, R., Steinmetz, H., Sasse, F., Schubert, W.-D., Hagelüken, G., Albrecht, S. C., 

Müller, R. (2008) Isolation and structure revision of the actin-binding macrolide rhizopodin 

from Myxococcus stipitatus (Myxobacteria). Tetrahedron Letters, 49 (40): 5796-5799. 

99. Pérez, J., Castañeda-García, A., Jenke-Kodama, H., Müller, R., Muñoz-Dorado, J. (2008) 

Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome, PNAS, 105 

(41): 15950-15955. 

98. Krug, D., Zurek, G., Schneider, B., Garcia, R., Müller. R. (2008) Efficient mining of 

myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionization- 

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time-of-flight mass spectrometry and compound-based principal component analysis, 

Analytica Chimica Acta, 624 (1): 97-106. 

97. Fu, J., Wenzel, S. C., Perlova, O., Wang, J., Gross, F., Tang, Z., Yin, Y., Stewart, A. F., 

Müller, R., Zhang, Y. (2008) Efficient transfer of two large secondary metabolite pathway 

gene clusters into heterologous hosts by transposition, Nucleic Acids Res, 36 (17): e133ff. 

96. Menche, D., Arikan, F., Perlova, O., Horstmann, N., Ahlbrecht, W., Wenzel, S. C., Jansen, 

R., Irschik, H., Müller, R. (2008) Stereochemical determination and complex biosynthetic 

assembly of etnangien, a highly potent RNA-polymerase inhibitor from the myxobacterium 

Sorangium cellulosum, J Am Chem Soc, 130 (43): 14234-14243. 

95. Wenzel, S. C., Bode, H. B., Kochems, I., Müller, R. (2008) A type I/type III polyketide 

synthase hybrid biosynthetic pathway for the structurally unique ansa compound 

kendomycin, ChemBioChem, 9 (16): 2711-2721. 

94. Li, Y., Weissman, K. J., Müller, R. (2008) Myxochelin biosynthesis: direct evidence for two- 

and four-electron reduction of a carrier protein-bound thioester, Journal of the American 

Chemical Society, 130 (24): 7554-7555. 

93. Meiser, P., Weissman, K. J., Bode, H. B., Krug, D., Dickschat, J. S., Sandmann, A., Müller, 

R. (2008) DKxanthene biosynthesis - Understanding the basis for diversity-oriented synthesis 

in myxobacterial secondary metabolism, ChemBiol, 15 (8): 771-781. 

92. Knauber, T., Doss, S. D., Gerth, K., Perlova, O., Müller, R., Treuner-Lange, A. (2008) 

Mutation in the rel gene of Sorangium cellulosum affects morphological and physiological 

differentiation, Molecular Microbiology, 69 (1): 254-266. 

91. Sandmann, A., Frank, B., Müller, R. (2008) A transposon-based strategy to scale up 

myxothiazol production in myxobacterial cell factories, Journal of Biotechnology, 135 (3): 

255-261. 

90. Krug, D., Zurek, G., Revermann, O., Vos, M., Velicer, G.J., Müller , R. (2008) Discovering 

the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity, 

Applied and Environmental Microbiology, 74 (10): 3058-3068. 

89. Meiser, P., Müller R. (2008) Two functionally redundant Sfp-type 4’-phosphopantetheinyl 

transferases differentially activate biosynthetic pathways in Myxococcus xanthus, 

ChemBioChem, 9 (10): 1549-1553. 

88. Buntin, K., Rachid, S., Scharfe, M., Blöcker, H., Weissman, K. J., Müller, R. (2008) 

Production of the Antifungal Isochromanone Ajudazols A and B in Chondromyces crocatus 

Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications, Angew Chem Int Ed, 

47 (24): 4595-4599. 

87. Nawrath, T., Dickschat, J. S., Müller, R., Jiang, J., Cane, D. E., Schulz, S. (2008) 

Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis 

of geosmin in bacteria , J. Am. Chem. Soc, 130 (2): 430-431. 

86. Bock, M., Buntin, K., Müller, R., Kirschning, A. (2008) Sterochemical determination of 

thuggacin A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum, 

Angew Chem Int Ed, 47 (12): 2308-2311. 

85. Petković, H., Sandmann, A., Challis, I. R., Hecht, H.-J., Silakowski, B., Low, L., Beeston, N., 

Kuščer, E., Garcia-Bernando, J., Leadlay, P.F., Kendrew, S.G., Wilkinson, B., Müller, R. 

7

(2008) Substrate specificity of the acyl transferase domains of EpoC from the epothilone 

polyketide synthase. Organic & Biomolecular Chemistry, 6 (3): 500-506. 

84. Binz, T. M., Wenzel, S. C., Schnell, H.-J., Bechthold, A., Müller R. (2008) Heterologous 

expression and genetic engineering of the phenalinolactone biosynthetic gene cluster using 

Red/ET recombineering. ChemBioChem, 9 (3): 447-454. 

83. Krug, D., Zurek, G., Schneider, B., Bässmann, C., Müller, R. (2007). Analysis of secondary 

metabolites from myxobacteria using ESI-TOF-MS and PCA. LC-GC Europe, The 

Applications Book, March 2007: 41-42. 

82. Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, 

T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. 

A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., 

Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, 

B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M. Meyer, F., Mormann, S, 

Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., 

Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., 

Vorhölter,F. J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., 

Wittmann, C., Blöcker, H., Pühler, A., Müller, R. (2007) Complete genome sequence of the 

myxobacterium Sorangium cellulosum. Nat Biotechnol, 25 (11): 1281-1289. 

81. Bode, H. B., Meiser, P., Klefisch, T., Socorro d. J. Cortina, N., Krug, D., Göhring, A., Schwär, 

G., Mahmud, T., Elnakady, Y. A., Müller, R. (2007) Mutasynthesis-derived myxalamids and 

origin of the isobutyryl-CoA starter unit of myxalamid B, ChemBioChem, 8 (17): 2139-2144. 

80. Frank, B., Wenzel, S. C., Bode, H. B., Scharfe, M., Blöcker, H., Müller, R. (2007) From 

genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and 

aurafuron-like structures in myxobacteria and streptomycetes. J Mol Biol, 374 (1): 24-38. 

79. Dickschat, J. S., Nawrath, T., Thiel, V., Kunze, B., Müller, R., Schulz, S. (2007) Biosynthesis 

of the Off-flavor 2-Methylisoborneol by the Myxobacterium Nannocystis exedens. Angew 

Chem Int Ed, 46 (43): 8287-8290. 

78. Rachid, S., Krug, D., Weissman, K., Müller, R. (2007) Biosynthesis of (R)-beta-tyrosine and 

its incorporation into the highly cytotoxic chondramides produced by Chondromyces 

crocatus, Journal of Biological Chemistry, 282 (30): 21810-21817. 

77. Simunovic, V., Müller, R. (2007) Mutational analysis of the myxovirescin biosynthetic gene 

cluster reveals novel insights into the functional elaboration of polyketide backbones, 

ChemBioChem, 8 (11): 1273-1280. 

76. Backes, C., Keller, A., Kuentzer, J., Kneissl, B., Comtesse, N., Elnakady, Y. A., Müller, R., 

Meese, E., Lenhof, H.-P. (2007) GeneTrail - advanced gene set enrichment analysis, 

Nucleic Acids Research, 35: W186-W192. 

75. Martens, T., Gram, L., Grossart, H. P., Kessler, D., Müller, R., Simon, M., Wenzel, S. C., 

Brinkhoff, T. (2007) Bacteria of the Roseobacter clade show potential for secondary 

metabolite production, Microbial Ecology, 54 (1): 31-42. 

74. Elnakady, Y. A., Rohde, M., Sasse, F., Backes, C., Keller, A., Lenhof, H.-P., Weissman, K. 

J., Müller, R. (2007) Evidence for the mode of action of the highly cytotoxic Streptomyces 

polyketide kendomycin, ChemBioChem, 8 (11): 1261-1272. 

8

73. Rupprath, C., Kopp, K., Hirtz, D., Irschik, H., Müller, R., Elling, L. (2007) An enzyme module 

system for in situ regeneration of dTDP-activated deoxysugars, Adv Synth Catal, 349: 1489- 

1496. 

72. Kopp, M., Rupprath, C., Irschik, H., Bechthold, A., Elling, L. Müller, R. (2007) SorF, a 

glycosyltransferase with promiscuous donor substrate specificity in vitro,' ChemBioChem, 8 

(7): 813-819. 

71. Janssen, D., Albert, D., Jansen, R., Müller, R., Kalesse, M. (2007) Chivosazole A - 

Elucidation of the full absolute and relative configuration. Angew Chem Int Ed, 46 (26): 

4898-4901. 

70. Rachid, S., Gerth, K., Kochems, I. Müller, R. (2007) Deciphering regulatory mechanisms for 

secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56, 

Molecular Microbiology, 63 (6):1783-1796. 

69. Simunovic, V., Müller, R. (2007) 3-Hydroxy-3-Methylglutaryl-CoA-like Synthases Direct the 

Formation of Methyl and Ethyl Side Groups in the Biosynthesis of the Antibiotic Myxovirescin 

A. ChemBioChem, 8 (5): 497-500. 

68. Frank, B., Knauber, J., Steinmetz, H., Scharfe, M., Blöcker, H., Beyer, S., Müller, R. (2007) 

Spiroketal polyketide formation in Sorangium: Identification and analysis of the biosynthetic 

gene cluster for the highly cytotoxic spirangienes. Chem Biol, 14: 221-233. 

67. Sandmann, A., Dickschat, J., Jenke-Kodama, H., Kunze, B., Dittmann, E., Müller, R. (2007) 

A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is 

involved in aurachin alkaloid biosynthesis. Angew Chem Int Ed, 46 (15): 2712-2716. 

66. Meiser, P., Bode, H. B., Müller, R. (2006) The unique DKxanthene secondary metabolite 

family from the myxobacterium Myxococcus xanthus is required for developmental 

sporulation. Proc Natl Acad Sci USA, 103 (50): 19128-19133. 

65. Gross, F., Ring, M. W., Perlova, O., Fu, J., Schneider, S., Gerth, K., Kuhlmann, S., Stewart, 

A. F., Zhang, Y., Müller R. (2006) Metabolic engineering of Pseudomonas putida for 

methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite 

formation. Chem Biol, 13: 1253-1264. 

64. Wenzel, S. C., Williamson, R. M., Grünanger, C., Xu, J., Gerth, K., Martinez, R. A., Moss, S. 

R., Carroll, B. J., Grond, S., Unkefer, C. J., Müller, R., Floss H. G. (2006) On the biosynthetic 

origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" 

units into ansamitocin and soraphen A, J Am Chem Soc, 128 (44): 14325-14336. 

63. Perlova, O., Fu, J., Kuhlmann, S., Krug, D., Stewart, A.F., Zhang, Y. Müller, R. (2006) 

Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and 

heterologous expression in Myxococcus xanthus. Appl Environ Microbiol, 72 (12): 7485- 

7494. 

62. Müller, I., Müller, R. (2006) Biochemical characterization of MelJ and MelK - Myxobacterial 

enzymes that transform an amide into a methyl ester. FEBS J, 273 (16): 3768-78. 

61. Stephan, S., Heinzle, E., Wenzel, S., Krug, D., Müller, R., Wittmann, C. (2006) Metabolic 

physiology of Pseudomonas putida for heterologous production of myxochromide. Process 

Biochemistry, 41: 2146-2152. 

60. Bode, H. B., Ring, M. W., Schwär, G., Kroppenstedt, R.M., Kaiser, D., Müller, R. (2006) 3- 

Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in the biosynthesis of 

9

isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation. J 

Bacteriol, 188 (18): 6524-6528. 

59. Schley, C., Altmeyer, M. O., Swart, R., Müller, R., Huber C. G. (2006) Proteome analysis of 

Myxococcus xanthus by off-line two-dimensional chromatographic separation using 

monolithic poly-(styrene-divinylbenzene) columns combined with ion-trap tandem mass 

spectrometry, Journal of Proteome Research, 5 (10): 2760-2768. 

58. Simunovic, V., Zapp, J., Rachid, S., Krug, D., Meiser, P. Müller, R. (2006) Myxovirescin A 

biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3hydroxy-3-methylglutaryl 

CoA synthases and trans-acting acyltransferases, ChemBioChem, 

7: 1206-1220. 

57. Müller, I., Weinig, S., Steinmetz, H., Kunze, B., Veluthoor, S., Mahmud, T., Müller, R. (2006) 

A unique mechanism for methyl ester formation via an amide intermediate found in 

myxobacteria. ChemBioChem, 7(8):1197-1205. 

56. Rachid, S., Krug, D., Kochems, I., Kunze, B., Scharfe, M., Blöcker, H., Zabriskie, M., Müller, 

R. (2006) Molecular and biochemical studies of chondramide formation - highly cytotoxic 

natural products from chondromyces crocatus cm c5. Chem. Biol. 14: 667-681. 

55. Berner, M., Krug, D., Bihlmaier, C., Vente, A., Müller, R., Bechthold, A. (2006) Genes and 

enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix 

espanaensis. J. Bact., 188 (7): 2666-2673. 

54. Wenzel, S. C., Meiser, P., Binz, T. M., Mahmud, T. Müller, R. (2006) Nonribosomal peptide 

biosynthesis: Point mutations and module skipping lead to chemical diversity, Angew. 

Chem. Int. Ed., 45 (14): 2296-2301. 

53. Gross, F., Luniak, N., Perlova, O., Gaitatzis, N., Jenke-Kodama, H., Gerth, K., Gottschalk, 

D., Dittmann, E., Müller, R. (2006) Bacterial type III polyketide synthases: Phylogenetic 

analysis and potential for the production of novel secondary metabolites by heterologous 

expression in pseudomonads, Archives of Microbiology, 185 (1): 28-38. 

52. Rachid, S., Sasse, F., Beyer, S. Müller, R. (2006) Identification of StiR, the first regulator of 

secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1, 

J. Biotechnol., 121 (4): 429-441. 

51. Kegler, C., Gerth, K. Müller, R. (2006) Establishment of a real-time PCR protocol for 

expression studies of secondary metabolite biosynthetic gene clusters in the G/C-rich 

myxobacterium Sorangium cellulosum So ce56, J. Biotechnol., 121 (2): 201-212. 

50. Perlova, O., Gerth, K. Kaiser, O. Hans, A., Müller, R. (2006) Identification and analysis of the 

chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium 

cellulosum So ce56, J. Biotechnol., 121 (2): 174-191. 

49. Müller, R., Gerth, K. (2006) Development of simple media which allow investigations into the 

global regulation of chivosazol biosynthesis with Sorangium cellulosum So ce56, J. 

Biotechnol., 121 (2): 192-200. 

48. Dickschat, J. S., Bode, H. B., Kroppenstedt, R. M., Müller, R., Schulz, S. (2005) Biosynthesis 

of iso-fatty acids in myxobacteria. Org. Biomol. Chem., 3 (15): 2824-2831. 

47. Jenke-Kodama, H., Sandmann, A., Müller, R., Dittmann, E. (2005) Evolutionary implications 

of bacterial polyketide synthases. Molecular Biology and Evolution, 22 (10): 2027-2039. 

10

46. Dickschat, J. S., Bode, H. B., Wenzel, S. C., Müller, R., Schulz, S. (2005) Biosynthesis and 

identification of volatiles released by the myxobacterium Stigmatella aurantiaca, 

ChemBioChem., 6 (11): 2023-2033. 

45. Dickschat, J. S., Bode, H. B., Mahmud, T., Müller, R., Schulz, S. (2005) A novel type of 

geosmin biosynthesis in myxobacteria, J Org Chem, 70 (13): 5174-5182. 

44. Bredenbruch, F., Nimtz, M., Wray, V., Morr, M., Müller, R., Häussler, S. (2005) Biosynthetic 

pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines, J. Bacteriol., 187 (11): 

3630-3635. 

43. Kunze, B., Reichenbach, H., Müller, R., Höfle, G. (2005) Aurafuron A and B, new bioactive 

polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). 

Fermentation, isolation, physico-chemical properties, structure and biological activity, J. 

Antibiot., 58 (4): 244-251. 

42. Kopp, M., Irschik, H., Pradella, S., Müller, R. (2005) Production of the tubulin destabilizer 

disorazol in Sorangium cellulosum: Biosynthetic machinery and regulatory genes, 

ChemBioChem, 6 (7): 1277-1286. 

41. Wenzel, S. C., Gross, F., Zhang, Y., Fu, J., Stewart, A. F., Müller, R. (2005) Heterologous 

expression of a myxobacterial natural products assembly line in pseudomonads via redE/T 

recombineering, Chem. Biol., 12 (3): 349-356. 

40. Bode, H. B., Dickschat, J. S., Kroppenstedt, R. M., Schulz, S., Müller, R. (2005) Biosynthesis 

of iso-fatty acids in myxobacteria: iso-even fatty acids are derived from α-oxidation of iso-odd 

fatty acids, J.A.C.S., 127 (2): 532-533. 

39. Gross, F., Gottschalk, D., Müller, R. (2005) Posttranslational modification of myxobacterial 

carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase, 

Appl. Microbiol. Biotechnol., 68 (1): 66-74. 

38. Wenzel, S.C., Kunze, B., Höfle, G., Silakowski, B., Scharfe, M., Blöcker, H., Müller, R. 

(2005) Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: 

Evidence for an iterative bacterial type I polyktetide synthase and for module skipping in 

nonribosomal peptide biosynthesis, ChemBioChem, 6 (2): 375-385. 

37. Gaitatzis, N., Kunze, B., Müller, R. (2005) Novel insights into siderophore formation in 

myxobacteria, ChemBioChem, 6 (2): 365-374. 

36. Gerth, K., Müller, R. (2005) Moderately thermophilic myxobacteria: Novel pontial for 

production of natural products Environmental Microbiology, 7 (6): 874-880. 

35. Mahmud, T., Wenzel, S. C., Wan, E., Wen, K. W., Bode, H.B., Gaitatzis, N., Müller, R. 

(2005) A novel biosynthetic pathway to isovaleryl-CoA in myxobacteria: The involvement of 

the mevalonate pathway, ChemBioChem, 6 (2), 322-330. 

34. Bode, H. B., Wenzel, S. C., Irschik, H., Höfle, G. Müller, R. (2004) Unusual biosynthesis of 

leupyrrins in the myxobacterium Sorangium cellulosum. Angew. Chem. Int. Ed., 43: 4163- 

4167. 

33. Sandmann, A., Sasse, F., and Müller, R. (2004) Identification and analysis of the core 

biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity, 

Chem. Biol., 11: 1071-1079. 

11

32. Duerfahrt, T., Eppelmann, K., Müller, R., Marahiel, M. A. (2004) Rational design of a 

bimodular model system for the investigation of heterocyclization in nonribosomal peptide 

biosynthesis, Chem. Biol., 11: 261-271. 

31. Kopp, M., Irschik, H., Gross, F., Perlova, O., Sandmann, S., Gerth, K., Müller, R. (2004) 

Critical variations of conjugational DNA transfer into secondary metabolite multiproducing 

Sorangium cellulosum strains So ce12 and So ce56: development of a mariner-based 

transposon mutagenesis system, J. Biotechnol., 107: 29-40. 

30. Dickschat, J. S., Wenzel, S. C., Bode, H. B., Müller, R., Schulz, S. (2004) Biosynthesis of 

volatiles by the myxobacterium Myxococcus xanthus, ChemBioChem, 5 (6): 778-787. 

29. Weinig, S., Hecht, H.-J., Mahmud, T., Müller, R. (2003) Melithiazol biosynthesis: Further 

insights into Myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl 

transferases, Chem. Biol., 10 (10): 939-952. 

28. Weinig, S., Mahmud, T., Müller, R. (2003) Markerless mutations in the myxothiazol 

biosynthetic gene cluster: A delicate megasynthetase with a superfluous nonribosomal 

peptide synthetase domain, Chem. Biol., 10 (10): 953-960. 

27. Bode, H. B., Irschik, H., Wenzel, S. C., Reichenbach, H., Müller, R., Höfle, G. (2003) The 

Leupyrrins: A Structurally Unique Family of Secondary Metabolites from the Myxobacterium 

Sorangium cellulosum, J. Nat. Prod., 66 (9): 1203-1206. 

26. Bode, H. B., Zeggel, B., Silakowski, B., Wenzel, S. C., Reichenbach, H. Müller, R. (2003) 

Steroid biosynthesis in prokaryotes: Identification of myxobacterial steroids and cloning of the 

first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca, 

Mol. Microbiol., 47 (2): 471-481. 

25. Franke, D., Lorbach, V., Esser, S., Dose, C., Sprenger, G.A., Halfar, M., Thömmes, J., 

Müller, R., Takors, R., Müller, M. (2003) (S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic Acid: 

Microbial Access with Engineered Cells of Escherichia coli and Applicability as Starting 

Material in Natural-Product Synthesis, Chem. Eur. J., 9 (17): 4188-4196. 

24. Mahmud, T., Bode, H. B., Silakowski, B., Kroppenstedt, R. M., Xu, M., Nordhoff, S., Höfle, 

G., Müller, R. (2002) A novel biosynthetic pathway providing precursors for fatty acid 

biosynthesis and secondary metabolite formation in myxobacteria, J. Biol. Chem., 277 (36): 

32768-32774. 

23. Gaitatzis, N., Silakowski, B., Kunze, B., Nordsiek, G., Blöcker, H., Höfle, G., Müller, R. (2002) 

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is 

directed by a novel type of modular polyketide synthase, J. Biol. Chem., 277 (15): 13082- 

13090. 

22. Arakawa, K., Müller, R., Mahmud, T., Yu, T.-W., Floss, H. G. (2002) Characterization of the 

Early Stage Aminoshikimate Pathway in the Formation of 3-Amino-5-hydroxybenzoic Acid: 

The RifN Protein Specifically Converts Kanosamine into Kanosamine 6-Phosphate, J.A.C.S., 

124 (36): 10644-10655. 

21. Gaitatzis, N., Hans, A., Müller, R., Beyer, S. (2001) The mtaA gene of the myxothiazol 

biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1 encodes a 

phosphopantetheinyl transferase that activates polyketide synthases and polypeptide 

synthetases, J. Biochemistry, 129 (1): 119-124. 

20. Gaitatzis, N., Kunze, B., Müller, R. (2001) In vitro reconstitution of the myxochelin 

biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterisation of a 

12

eductive release mechanism from nonribosomal peptide synthetases. Proc. Nat. Acad. Sci. 

(USA), 98 (20): 11136-11141. 

19. Silakowski, B., Nordsiek, G., Kunze, B., Blöcker, H., Müller, R. (2001) Novel features in a 

combined polyketide synthase/non-ribosomal peptide synthetase: The myxalamid 

biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sg a15, Chem. Biol., 

8 (1): 59-69. 

18. Yu, T., Müller, R., Müller, M., Zhang, X., Dräger, G., Kim, C-G., Leistner, E., Floss, H.G. 

(2001) Mutational analysis and reconstituted expression of the biosynthetic genes involved in 

the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in 

Amycolatopsis mediterranei S699., J. Biol. Chem., 276 (16): 12546-12555. 

17. Silakowski, B., Kunze, B., Müller, R. (2001) Multiple hybrid polyketide synthase/nonribosomal 

peptide synthetase gene clusters the myxobacterium Stigmatella aurantiaca, 

Gene, 275 (2): 233-240. 

16. Buss, K., Müller, R., Dahm, C., Gaitatzis, N., Skrypczak-Pietrszek, E., Lohmann, S., Gassen, 

M., Leistner, E. (2001) Clustering of isochorismate synthase genes menF and entC and 

channeling of isochorismate in Escherichia coli, Biochim. Biophys. Acta, 1522 (3): 151-157. 

15. Müller, R., Gerth, K., Brandt, P., Blöcker, H., Beyer, S. (2000) Identification of an L-dopa 

decarboxylase gene from Sorangium cellulosum So ce90, Arch. Microbiol. 173 (4): 303- 

306. 

14. Silakowski, B., Kunze, B., Müller, R. (2000) Stigmatella aurantiaca Sg a15 carries genes 

encoding type I and type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthases: 

involvement of a type II synthase in aurachin biosynthesis. Arch. Microbiol., 173 (5-6): 403- 

411. 

13. Silakowski, B., Kunze, B., Nordsiek, G., Blöcker, H., Höfle, G., Müller, R. (2000) The 

myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15, Eur. 

J. Biochem. 267 (21): 6476-6485. 

12. Chen, S., von Bamberg, D., Hale, V., Breuer, M., Hardt, B., Müller, R., Floss, H.G., 

Reynolds, K. A., Leistner, E. (1999) Biosynthesis of ansatrienin (mycotrienin) and 

naphtomycin: Identification and analysis of two separate biosynthetic gene clusters in 

Streptomyces collinus TÜ 1892, Eur. J. Biochem. 261 (1), 98-107. 

11. Beyer, S., Kunze, B., Silakowski, B., Müller, R. (1999) Metabolic diversity in myxobacteria: 

identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella 

aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilon 

producing strain Sorangium cellulosum So ce90, Biochim. Biophys. Acta. 1445 (2): 185- 

195. 

10. Silakowski, B., Schairer, H. U., Ehret, H., Kunze, B., Weinig, S., Norsiek, G., Blöcker, H., 

Höfle, G., Beyer, S. Müller, R. (1999) New lessons for combinatorial biosynthesis from 

Myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1, 

J. Biol. Chem. 274 (52): 37391-37399. 

9. Dahm, C., Müller, R., Schulte, G., Schmidt, K., Leistner, E. (1998) The role of isochorismate 

hydroxymutase genes entC aned menF in enterobactin and menaquinone biosynthesis in 

Escherichia coli, Biochim. Biophys. Acta, 1425 (2): 377-386. 

8. August, P. R., Tang, L., Yoon, Y. J., Ning, S., Müller, R., Yu, T.W., Taylor, M., Hoffmann, D., 

Kim, C-G., Zhang, X., Hutchinson, C.R., Floss, H.G. (1998) Biosynthesis of the ansamycin 

13

antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene 

cluster of Amycolatopsis mediterranei S699, Chem. Biol. 5 (2): 69-79. 

7. Müller, M., Müller, R., Yu, T., Floss, H.G. (1998) Synthesis of (-)-3-amino-3-deoxyquinic 

acid, J. Org. Chem. 63: 9753-9755. 

6. Ledüc, C., Birgel, I., Müller, R., Leistner, E. (1997) Isochorismate hydroxymutase from a cellsuspension 

culture of Galium mollugo L., Planta, 202 (2): 206-210. 

5. Müller, R., Dahm, C., Schulte, G., Leistner, E. (1996) An isochorismate hydroxymutase 

isogene in Escherichia coli, FEBS Letters, 378 (2): 131-134. 

4. Müller, R., Kuttler, E., Lanz, C., Drewke, C., Schmidt, K. (1996) Isolation of a gene encoding 

cysteine synthase from Flavobacterium K3-15, FEMS Microbiol. Letters. 136 (3): 305-308. 

3. Müller, R., Breuer, M., Wagener, A., Schmidt, K., Leistner, E. (1996) Bacterial production of 

transdihydroxycyclohexadiene carboxylates by metabolic pathway engineering, 

Microbiology, 142 (4): 1005-1012. 

2. Drewke, C., Klein, M., Clade, D., Arenz, A., Müller, R., Leistner, E. (1996) 4-O-Phosphoryl-Lthreonine, 

a substrate of the pdxC (serC) gene product involved in vitamin B6 biosynthesis, 

FEBS Letters, 390 (2): 179-182. 

1. Müller, R., Wagener, A., Schmidt, K., Leistner, E. (1995) Microbial production of specifically 

ring- 13 C-labelled 4-hydroxybenzoic acid, Appl. Microbiol. Biotechnol., 43 (6): 985-988. 

14

II. Review articles in peer reviewed journals 

18. Weissman, K. J., Müller, R. (2010) Myxobacterial secondary metabolites: bioactivities and 

modes-of-action, Natural Product Reports, 27(9): 1276-1295. 

17. Wenzel, S. C., Müller, R. (2009) The impact of genomics on the exploitation of the 

myxobacterial secondary metabolome, Natural Product Reports, 26 (11): 1385-1407. 

16. Li, Y., Müller, R. (2009) Non-modular polyketide synthases in myxobacteria. Phytochemistry, 

70 (15-16):1850-1857. 

15. Garcia, R. O., Krug, D., Müller, R. (2009) Discovering Natural Products from Myxobacteria 

with Emphasis on rare Producer Strains in Combination with improved analytical Methods. 

Methods in Enzymology, 458 (Chapter 3): 59-91. 

14. Wenzel, S. C., Müller, R. (2009) Myxobacteria – ‘microbial factories’ for the production of 

bioactive secondary metabolites. Molecular BioSystems, 5:567-574. 

13. Wenzel, S. C., Müller, R. (2009) The biosynthetic potential of myxobacteria and their impact 

on drug discovery. Current Opinion in Drug Discovery & Development, 12 (2): 220-230. 

12. Weissman, K. J., Müller, R. (2009) A brief tour of myxobacterial secondary metabolism, 

Bioorganic & Medicinal Chemistry, 17 (6): 2121-2136. 

11. Weissman, K. J., Müller, R. (2008) Crystal structure of a molecular assembly line, Angew 

Chem Int Ed, 47 (44): 8344-8346. 

10. Weissman, K. J., Müller, R. (2008) Protein-protein interactions in multienzyme 

megasynthetases. ChemBioChem, 9 (6): 826-48. 

9. Wenzel, S.C., Müller, R. (2007) Myxobacterial natural product assembly lines: Fascinating 

examples of curious biochemistry, Natural Products Reports, 24 (6): 1211-1224. 

8. Bode, H. B., Müller, R. (2007) Reversible sugar transfer by glycosyltransferases as a tool for 

natural product (bio)synthesis. Angew Chem Int Ed, 46 (13): 2147-2150. 

7. Bode, H. B., Müller, R. (2006) Analysis of myxobacterial secondary metabolism goes 

molecular, J. Ind. Microbiol. Biotechnol., 33 (7): 577-88. 

6. Wenzel, S.C., Müller, R. (2005) Recent developments towards the heterologous expression 

of complex bacterial natural product biosynthetic pathways, Curr. Opin. Biotechnol., 16: 594- 

606. 

5. Wenzel, S.C., Müller, R. (2005) Formation of novel secondary metabolites by bacterial 

multimodular assembly lines: Deviations from text book biosynthetic logic. Curr Opin Chem 

Biol, 9: 447-458. 

4. Bode, H. B., Müller, R. (2005) The impact of bacterial genomics on natural product research, 

Angew. Chem. Int. Ed., 44: 6828-6846. 

3. Müller, R. (2004) Don`t classify polyketide synthases, Chem. Biol., 11: 4-6. 

2. Gerth, K., Pradella, S., Perlova, O., Beyer, S., Müller, R. (2003) Myxobacteria: Proficient 

producers of novel natural products with various biological activities – past and future 

15

iotechnological aspects with the focus on the genus Sorangium, J. Biotechnol., 106: 233- 

253. 

1. Bode, H. B., Müller, R. (2003) Possibility of bacterial recruitment of plant genes associated 

with the biosynthesis of secondary metabolites. Plant Physiol. 132, 1153-1161. 

16

III. Review articles in other journals 

13. Wenzel,S.C.; Müller,R. (2011) Naturstoffbiotechnologie des Myxobakteriums Chondromyces 

crocatus. Biospektrum, 5 (11), 580-582. 

13. Müller,R., Gerth,K. (2009) Von Mega-Genomen und Mikro-Chemikern: Neue Perspektiven 

für die Wirkstoffproduktion in Myxobakterien. Forschungsbericht 2008/2009, Helmholtz 

Zentrum für Infektionsforschung, Braunschweig: 22-29 

12. Müller, R. (2008) Plant Biochemistry and Biotechnology Lecture. SWISS PHARMA, 10: 10- 

11 

11. Mulzer, J., Altmann, K.-H., Höfle, G., , Prantz, K. (2008) Epothilones - A fascinating family of 

microtubule stabilizing antitumor agents. C. R. Chimie, 11 : 1336e-1368 

10. Perlova O, Gerth K, Müller R. (2008) Analyse des größten bekannten Bakteriengenoms: 

Neue Perspektiven für die Wirkstoff-Produktion in Sorangium cellulosum. GenomXpress, 

1.08: 4-7 

9. Müller, R. (2008) Neue Therapeutika aus Myxobakterien. magazin forschung, 1: 9-13 

8. Frank, B., Müller, R. (2007) Fachgruppen Workshop Biologie Naturstoff-produzierender 

Bakterien. Biospektrum 7, 784. 

7. Frank, B., Müller, R. (2007) Neue Wirkstoffe aus Myxobakterien: Wie Mikro-organismen den 

Krebs bekämpfen helfen. Pharmazeutische Zeitung 50, 64-67. 

6. Müller, R. (2006) Exploiting microbial diversity and bacterial genomics to find novel 

antibiotics. Int J Med Microbiol 296S3 (42): 138-9 

5. Wenzel, S. C., Müller, R. (2005) Heterologe Expression von komplexen myxobakteriellen 

Naturstoff-Biosynthesewegen in Pseudomonaden, Biospektrum, 11 (5), 628-631 

4. Beyer, S., Müller, R. (2001) Molecular biology of Secondary Metabolites in Myxobacteria, 

Annual Report 2001 (GBF - German Research Centre for Biotechnology Ltd.), 108-110 

3. Müller, R. (2000) Irseer Naturstofftage: Aktuelle Entwicklungen in der Naturstoff-Forschung, 

transcript 6, 4, 32-34 

2. Müller, R., Beyer, S. (2000) Genetics of Secondary Metabolism in Myxobacteria, Annual 

Report 1999/2000 (GBF - German Research Centre for Biotechnology Ltd.), 105-106 

1. Beyer, S., Müller, R. (1999) Molecular Biology of Secondary Metabolism in Myxobacteria, 

Scientific Annual Report 1998 (GBF - Gesellschaft für Biotechnologische Forschung), 31-33 

17

IV. Book Chapters 

5. Wenzel, S. C., Müller, R. (2010) Myxobacteria – Unique Microbial Secondary Metabolic 

Factories. In: Mander, L.N., Liu, H.W. (Eds) Comprehensive Natural Products II: Chemistry 

and Biology, Volume 2: Structural Diversity II – Secondary Metabolites: Sources, Structures 

and Chemical Biology, Elsevier Science & Technology, Oxford, 189-222 

4. Müller, R. (2009) Biosynthesis and heterologous production of epothilones. In: Mulzer, J. 

(Ed) The Epothilones, an Outstanding Family of Anti-Tumor Agents. Springer, New York, 29- 

53 

3. Jenke-Kodama, H., Müller, R., Dittmann, E. (2008) Evolutionary Mechanisms underlying 

secondary metabolite diversity. In: Petersen, F., Amstutz, R. (Eds) Progress in Drug 

Research, 65: 119, 121-140 

2. Bode, H. B., Müller, R. (2007) Secondary metabolism in myxobacteria. In: Whitworth, D. (Ed) 

Myxobacteria: Multicellularity and differentiation. ASM press, Chicago, 259-282 

1. Gerth, K., Perlova, O., Müller, R. (2007) Sorangium cellulosum. In: Whitworth, D. (Ed) 

Myxobacteria: Multicellularity and differentiation. ASM press, Chicago, 329-348 

18

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