Abdi, Camillo Ricordi, Mohamed H. Sayegh, Antonello Pileggi and ...

21 DOI: 10.1161/CIRCULATIONAHA.112.123653 9. Ariyan C, Salvalaggio P, Fecteau S, Deng S, Rogozinski L, M<strong>and</strong>elbrot D, Sharpe A, <strong>Sayegh</strong> MH, Basadonna GP, Rothstein DM. Cutting edge: Transplantation tolerance through enhanced ctla-4 expression. J Immunol. 2003;171:5673-5677. 10. King CL, Devitt JJ, Lee TD, Hancock Friesen CL. Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy. J Cardiothorac Surg. 2010;5:52. 11. Shen X, Reng F, Gao F, Uchida Y, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Alloimmune activation enhances innate tissue inflammation/injury in a mouse model of liver ischemia/reperfusion injury. Am J Transplant. 2010;10:1729-1737. 12. Novak I. Atp as a signaling molecule: The exocrine focus. News Physiol Sci. 2003;18:12-17. 13. Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravich<strong>and</strong>ran KS. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461:282-286. 14. Schenk U, Westendorf AM, AM, Radaelli E, Casati A, Ferro M, Fumagalli M, Ver Verderio erde derio o C, Bue Buer ue u r JJ, Scanziani Scanziani E, Grassi F. Purinergic control of t cell activation by atp released through throug ugh pannexin-1 pa pann nn nnex exin in in-1 -1 hemichannels. Sci Signal. 2008;1:ra6. 2008;1:ra6. 15. . Pi Picc Piccini cc ccin in ini i A, AA, Car Carta ar arta ta S, Tassi S, Lasiglie D, Fossat Fossati ati G, Rubartelli A. AA. Atp tp is released by monocytes stimulated tim im imul ulated with h pathogen-sensing pa path thog og ogen en en-s -sen ensi sing ng receptor rec ecep epto tor r lig<strong>and</strong>s li liga ga g nd nds <strong>and</strong> induces in indu du duce c s il-1beta il il-1 -1be beta ta <strong>and</strong> nd il-18 ill-18 18 secretion sec ecre reti ti tion on in n an a autocr autocrine c ine way. y Pr PProc oc Natl Ac Acad ad Sci ci U S A. 2008;105 2008;105:8067-8072. 05 05:806 06 067- 7-80 80 8 72 72. 16. Ra Rale Ralevic le l vi vic c V, VV, Burnstock Burns nstock G. Receptors Re Rece ce cept pt ptor ors s for fo for pu puri purines ri rine ne nes <strong>and</strong> d py pyri pyrimidines. ri rimi mi midi di d ne nes. s. Ph Pharma Pharmacol maco col l Re Rev. 1998 1998;50:413-492. 98;5 ;50:41 413- 3 49 492. 17 17. Khakh Kh Khak akh BS, BS North No Nort rth RA. RA P2x P2 P2x receptors re rece cept ptor ors as cell-surface cel ell-sur urfa face ce atp tp sen sensors enso sors rs in he heal health alth th <strong>and</strong> nd dis disease. isea ease se Na Natu Nature. ture re 2006;442:527-532. 18. Wilhelm K, Ganesan J, Muller T, Durr C, Grimm M, Beilhack A, Krempl CD, Sorichter S, Gerlach UV, Juttner E, Zerweck A, Gartner F, Pellegatti P, Di Virgilio F, Ferrari D, Kambham N, Fisch P, Finke J, Idzko M, Zeiser R. Graft-versus-host disease is enhanced by extracellular atp activating p2x7r. Nat Med. 2010;16:1434-1438. 19. Junger WG. Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol. 2011;11:201-212. 20. Casati A, Frascoli M, Traggiai E, Proietti M, Schenk U, Grassi F. Cell-autonomous regulation of hematopoietic stem cell cycling activity by atp. Cell Death Differ. 2011;18:396- 404. 21. Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. Pannexin-1 hemichannel-mediated atp release together with p2x1 <strong>and</strong> p2x4 receptors regulate t-cell Downloaded from http://circ.ahajournals.org/ by guest on December 19, 2012

activation at the immune synapse. Blood. 2010;116:3475-3484. 22 DOI: 10.1161/CIRCULATIONAHA.112.123653 22. Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K. Atp drives lamina propria t(h)17 cell differentiation. Nature. 2008;455:808-812. 23. Schenk U, Frascoli M, Proietti M, Geffers R, Traggiai E, Buer J, <strong>Ricordi</strong> C, Westendorf AM, Grassi F. Atp inhibits the generation <strong>and</strong> function of regulatory t cells through the activation of purinergic p2x receptors. Sci Signal. 2011;4:ra12. 24. Chadha R, Heidt S, Jones ND, Wood KJ. Th17: Contributors to allograft rejection <strong>and</strong> a barrier to the induction of transplantation tolerance? Transplantation. 2011;91:939-945. 25. Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, <strong>Sayegh</strong> MH, Ansari MJ. A novel role of cd4 th17 cells in mediating cardiac allograft rejection <strong>and</strong> vasculopathy. J Exp Med. 2008;205:3133-3144. 26. Clayton A, Al-Taei S, Webber J, Mason MD, Tabi Z. Cancer exosomes express expres ess s cd39 cd c 39 <strong>and</strong> nd cd73, which suppress t cells through adenosine production. J Immunol. Immunol. 2011;187 2011;187:676-683. 87:6 :676 76 7 -6 -683 83 83. 27. Placido R, Auricchio G, Falzoni S, Battistini L, Colizzi V, Brunetti E, Di Virgilio F, Mancino G. G. P2x(7) purinergic receptors <strong>and</strong> extracellular atp p mediate apoptosis of human monocytes/macrophages mo mono nocy cy cyte te tes/ s/ s/macrop op opha h ges infected with mycobacterium mycobact ct cter e ium tuberculosis i reducing red educ ucing the intracellular bacterial ba baacteria i l viab viability. abilit ity. y. Cell Ce Cell ll Immunol. Imm mm mmun unol ol ol. 20 22006;244:10-18. 06 06;2 ;2 ; 44 44:1 :10- 0-18 18. 28. 28 28. Murgia Mu M rgia M, Hanau S, Pizzo Piz izzo zo P, Rippa Ri Ripp ppa a M, Di Virgilio Virg rgil ilio io F. Oxidized Ox Oxidized atp. An irreversible irrev e ersibl ble inhibitor inhibi bitor of the he mac macrophage acro ro roph phag ag age pu puriner purinergic ergic c p2 p2z re rece receptor. cept pt ptor or or. J Bi Biol ol Che Chem. hem. 19 1993 1993;268:8199-8203. 93 93;2 ;268 68:8 :8 :819 199- 9-82 8203 03 03. 29. Stewart S, Win Winters inte te ters rs GL, L, Fis Fishbein i hb hbei ei e n MC MC, Ta Taze Tazelaar ze zela la laar ar HD, D, Kob Kobashigawa ob obas ashi hi higaw aw awa a J, JJ, Abr Abrams br b am ams s J, And Andersen n ersen CB, CB Angelini An Ange geli lini ni A, A Berry Be Berr rry GJ, GJ Burke Bu Burk rke MM, MM Demetris De Deme metr tris is AJ, AJ Hammond Ham ammo mond nd E, E Itescu It Ites escu cu S, S Marboe Ma Marb rboe oe CC, CC McManus B, Reed EF, Reinsmoen NL, Rodriguez ER, Rose AG, Rose M, Suciu-Focia N, Zeevi A, Billingham ME. Revision of the 1990 working formulation for the st<strong>and</strong>ardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710-1720. 30. Bruschi G, Colombo T, Oliva F, Morici N, Botta L, Cannata A, Frigerio M, Martinelli L. Orthotopic heart transplantation with donors greater than or equal to 60 years of age: A singlecenter experience. Eur J Cardiothorac Surg. 2011;40:e55-61. 31. Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, <strong>Sayegh</strong> MH. The emerging role of t cell ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest. 2008;118:742-751. 32. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of h-2d, h-2k, <strong>and</strong> non-h-2 antigens in rejection. Transplantation. 1973;16:343-350. Downloaded from http://circ.ahajournals.org/ by guest on December 19, 2012