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Collagen Fibers Fawad Mueen Arbi
Roll # 159
Introduction
 Most commonly occurring connective tissue
fibers.
 Most abundant protein in mammals (25-35% of
all proteins)
 Made up of collagen protein (Type I fibrils)
 These fibers are flexible but inelastic.
 Their diameter is 2-10 μm.
 Found in Cartilage, Bone, Tendon and
Ligament
Structure
 In LM, it appears interwoven running
randomly in all directions.
 When not under stress, they show wavy
pattern
 In EM, it shows collagen fiber is further
made of parallel fibrils which have diameter
of 50-90 nm.
 The gap between two collagen molecules
is called Lacunar Zone.
Collagen Fibers in
Tendon
Reticular fibers
introduction
 Much thinner than collagen fibers with diameter of 0.5-2 m.μ
 Made up of collagen protein (Type III fibrils)
 It is visualized by Silver staining and PAS staining.
 Also called Argyrophilic Fibers.
 Present in Lymph Nodes, Spleen, Liver, Endocrine Glands, Bone Marrow,
Endomysium and Endoneurium
production
 Bone Marrow and Lymph Nodes –
Reticular Cells
 Liver, Spleen, Endocrine Glands –
Fibroblasts
 Endoneurium – Schwann Cells
 GIT and Arteries – Smooth Muscle
Cells
Reticular Fibres in
Spleen
Collagen fibers & Reticular fibers

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Collagen fibers & Reticular fibers

  • 1. Collagen Fibers Fawad Mueen Arbi Roll # 159
  • 2. Introduction  Most commonly occurring connective tissue fibers.  Most abundant protein in mammals (25-35% of all proteins)  Made up of collagen protein (Type I fibrils)  These fibers are flexible but inelastic.  Their diameter is 2-10 μm.  Found in Cartilage, Bone, Tendon and Ligament
  • 3. Structure  In LM, it appears interwoven running randomly in all directions.  When not under stress, they show wavy pattern  In EM, it shows collagen fiber is further made of parallel fibrils which have diameter of 50-90 nm.  The gap between two collagen molecules is called Lacunar Zone.
  • 4.
  • 7. introduction  Much thinner than collagen fibers with diameter of 0.5-2 m.μ  Made up of collagen protein (Type III fibrils)  It is visualized by Silver staining and PAS staining.  Also called Argyrophilic Fibers.  Present in Lymph Nodes, Spleen, Liver, Endocrine Glands, Bone Marrow, Endomysium and Endoneurium
  • 8. production  Bone Marrow and Lymph Nodes – Reticular Cells  Liver, Spleen, Endocrine Glands – Fibroblasts  Endoneurium – Schwann Cells  GIT and Arteries – Smooth Muscle Cells