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Physiotherapist - Masters in Neurology

PAIN PATHWAY - “Routeway of unpleasant sensation “ Pain plays an important in the survival of all animals. It acts as a signal, alerting us to potential tissue damage, and leads to a wide range of actions to prevent or limit further damage. Physiologically, pain occurs when sensory nerve endings called nociceptors (also referred to as pain receptors) come into contact with a painful or noxious stimulus. The resulting nerve impulse travels from the sensory nerve ending to the spinal cord, where the impulse is rapidly shunted to the brain via nerve tracts in the spinal cord and brainstem. The brain processes the pain sensation and quickly responds with a motor response in an attempt to cease the action causing the pain. Nociceptive Pathways The classic nociceptive pathway involves three types of neurons: Primary sensory neurons in the peripheral nervous system, which conduct painful sensations from the periphery to the dorsal root of the spinal cord Secondary sensory neurons in the spinal cord or brainstem, which transmit the painful sensation to the thalamus Tertiary sensory neurons, which transmit the painful sensation from the thalamus to the somatosensory areas of the cerebral cortex. There are two major classes of nerve fibers associated with the transmission of pain: Unmyelinated C fibers Myelinated A-delta fibers Destinations of the Spino­thalamic and Spinoreticular Tracts in the Brain A illustration of the destinations of the spino­thalamic and spinoreticular tracts in the brain The thalamus is the destination of spinothalamic tract—the sensory pathway responsible for processing pain, temperature, and crude touch. The brainstem reticular formation, which forms a diffuse, central core within the brainstem is the destination of the spinoreticular tract. Source: 3DScience.com. Used by permission. The C fibers are small and conduct impulses slowly. They respond to thermal, mechanical, and chemical stimuli and produce the sensation of dull, diffuse, aching, burning, and delayed pain. A-delta fibers, which are myelinated and thus conduct impulses rapidly, respond to mechanical (pressure) stimulus and produce the sensation of sharp, localized, fast pain. One of the most important central pain pathways is the spinothalamic tract, which originates in the spinal cord and extends to the thalamus. This spinal tract transmits sensory information related to pain, temperature, and crude touch. Another prominent pathway is the spino­reticular tract, which is involved in noci­ceptive processing. The spino­reticular tract is similar to the spino­thalamic tract in that it is excited by similar sensory fibers. Rather than ascending to the thalamus however, spino­reticular neurons terminate within the brainstem.

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