Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on

Mrinmoy Maiti; Shin A Yoon; Yujin Cha; K. K. Athul; Sankarprasad Bhuniya; Min Hee Lee

doi:10.1039/D1CC00118C

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Cell-specific activation of gemcitabine by endogenous H₂S stimulation and tracking through simultaneous fluorescence turn-on†

Mrinmoy Maiti,‡^a Shin A Yoon,‡^b Yujin Cha,^b K. K. Athul,^c Sankarprasad Bhuniya

*^c and Min Hee Lee

*^b

Author affiliations

* Corresponding authors

^a Department of Science, School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, India

^b Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea
E-mail: minheelee@sookmyung.ac.kr

^c Centre for Interdisciplinary Science, JIS Institute of Advanced Studies and Research, JIS University, Salt Lake, Kolkata, India
E-mail: spbhuniya@jisiasr.org

Abstract

The endogenous H₂S-driven theranostic H₂S-Gem has been invented. The theranostic prodrug H₂S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H₂S-Gem selectively inhibited cancer cell growth compared to the mother chemotherapeutic gemcitabine. Overall, it is a unique protocol for tracking and transporting chemotherapeutic agents to tumor areas without the guidance of tumor-directive ligands.

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Article information

DOI: https://doi.org/10.1039/D1CC00118C
Article type: Communication
Submitted: 08 Jan 2021
Accepted: 23 Aug 2021
First published: 23 Aug 2021

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Chem. Commun., 2021,57, 9614-9617

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Cell-specific activation of gemcitabine by endogenous H₂S stimulation and tracking through simultaneous fluorescence turn-on

M. Maiti, S. A. Yoon, Y. Cha, K. K. Athul, S. Bhuniya and M. H. Lee, Chem. Commun., 2021, 57, 9614 DOI: 10.1039/D1CC00118C

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