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Oocyte Denuding

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Practical Manual of In Vitro Fertilization

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Abstract

The term oocyte denuding refers to the removal of the somatic cell layers that surround the oocytes. During the preovulatory growth, within the follicle, the oocyte is surrounded by two different cell layers: granulosa and thecal cells that sustain oocyte nutrition and maturation providing essential metabolites, hormones, and growth factors. However, the oocentric perspective of folliculogenesis highlights the central role of the oocyte itself in directing its own development as well as the follicle differentiation. In this regard, the oocyte is deemed capable of modulating the follicular environment in order to guarantee correct preantral, antral, and preovulatory development.

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Authors and Affiliations

  1. GENERA Centre for Reproductive Medicine, Clinica Valle Giulia, Rome, Italy

    Roberta Maggiulli PhD, Filippo Ubaldi MD, MSc & Laura Rienzi MSc

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  1. Roberta Maggiulli PhD
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  2. Filippo Ubaldi MD, MSc
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  3. Laura Rienzi MSc
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Correspondence to Roberta Maggiulli PhD .

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Editors and Affiliations

  1. , Scientific and Laboratory Director, Reproductive Biology Associates, Atlanta, 30342, Georgia, USA

    Zsolt Peter Nagy

  2. , Sr. Embryologist, Montreal Reproductive Centre, Montreal, H4A 3J3, Québec, Canada

    Alex C. Varghese

  3. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Maggiulli, R., Ubaldi, F., Rienzi, L. (2012). Oocyte Denuding. In: Nagy, Z., Varghese, A., Agarwal, A. (eds) Practical Manual of In Vitro Fertilization. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1780-5_12

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  • DOI: https://doi.org/10.1007/978-1-4419-1780-5_12

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