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Quinone diterpenes from Salvia species: chemistry, botany, and biological activity

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Abstract

A total of 175 abietane quinone diterpenes with ortho- or para-quinone chromophore, namely 11,12-ortho-quinone abietane, 11,14-para-quinone abietane, seco-abietane and abeo-abietanes quinones were surveyed from 130 species of Salvia of central Asia/Mediterranean area, eastern Asia, and Central and South America. An organized information on the phytochemistry and the biological activities, i.e. anti-cancer, antioxidant, anxiolytic and antidepressant, anti-obesity, antinflammatory, as well as antimicrobial and toxicological aspects of these compounds was provided. Due to the many nomenclatural mistakes caused by the abundance of data, and the need to provide the plant knowledge for further chemotaxonomic studies, the results about the botany and the taxonomy of the plant source of these compounds were also summarized.

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Funding

This study was funded by INTERREG V-A Francia-Italia (ALCOTRA) (2014–2020) Project “ANTEA–Attività innovative per lo sviluppo della filiera transfrontaliera del fiore edule” (No. 11039).

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Author notes

  1. Francesca Pedrelli and Massimiliano D’Ambola have contributed equally to this work.

Authors and Affiliations

  1. Dipartimento di Farmacia, Università di Genova, Genoa, Italy

    Angela Bisio & Francesca Pedrelli

  2. Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II, Fisciano, SA, Italy

    Massimiliano D’Ambola & Nunziatina De Tommasi

  3. Dipartimento di Scienze, Università degli Studi della Basilicata, Viale dell’Ateneo Lucano 10, 85100, Potenza, Italy

    Fabiana Labanca & Luigi Milella

  4. Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Sezione di Microbiologia, Università di Genova, Largo Rosanna Benzi 8, 16145, Genoa, Italy

    Anna Maria Schito

  5. Biodiversity Informatics and Spatial Analysis Royal Botanic Gardens, Kew Jodrell Laboratory, Kew Road, Richmond, TW9 3DS, UK

    Rafaël Govaerts

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  1. Angela Bisio
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Appendix

Appendix

See Table 6.

Table 6 Synonyms, lifeform, geographical distribution and ecology of the selected Salvia speciesa
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Bisio, A., Pedrelli, F., D’Ambola, M. et al. Quinone diterpenes from Salvia species: chemistry, botany, and biological activity. Phytochem Rev 18, 665–842 (2019). https://doi.org/10.1007/s11101-019-09633-z

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