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Albumin roles in developing anticancer compounds

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Abstract

Albumin is an abundant protein in nature with several biological functions. In the human body, both in health and in illness, its transport function is highlighted by the binding to medicinal drugs and consequent distribution in the bloodstream to the site of action. This is particularly relevant for anticancer treatments, since this protein accumulates in the tumor microenvironment to supply the energetic demands of cancer cells. Different spectroscopy, thermodynamic and in silico studies techniques can be employed to verify how albumin binds to ligands by using either human serum albumin (HSA) or bovine serum albumin (BSA) due to their structural similarity. There is an increasing tendency to use albumin in analyses of absorption, distribution, metabolism and excretion (ADME) properties of anticancer molecules, which further demonstrated the promising character of this investigation for proposing new drugs.

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Acknowledgements

The authors would like to thank the Foundation of Support to Sciences and Technology in Pernambuco [Fundação de Amparo à Ciência e Tecnologia de Pernambuco – FACEPE], Brazil, grant numbers APQ-0378-4.03/18 and APQ-0166-4.03/19) for the financial support. This study was partly funded by the Coordination for the Improvement of Higher Education Personnel, Brazil [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)] - Finance Code 001. The authors are thankful to Doctor Larissa de P. Cavalcanti (laracvanti@gmail.com) from Universidade Federal Rural de Pernambuco, Unidade Acadêmica de Serra Talhada (UFRPE/UAST) for proof-reading the manuscript.

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  1. Laboratório de Química e Inovação Terapêutica (LQIT) – Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, PE, Brazil

    Amélia Galdino Ribeiro, José Cleberson Santos Soares, Keriolaine Lima dos Santos, Sinara Mônica Vitalino de Almeida & Maria do Carmo Alves de Lima

  2. Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Recife, PE, Brazil

    Josival Emanuel Ferreira Alves, Íris Trindade Tenório Jacob & Sinara Mônica Vitalino de Almeida

  3. Laboratório de Biologia Molecular, Universidade de Pernambuco, campus Garanhuns, Garanhuns, PE, Brazil

    Cindy Juliane da Silva Ferreira, Jéssica Celerino dos Santos, Rafael David Souto de Azevedo & Sinara Mônica Vitalino de Almeida

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  1. Amélia Galdino Ribeiro
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Ribeiro, A.G., Alves, J.E.F., Soares, J.C.S. et al. Albumin roles in developing anticancer compounds. Med Chem Res 30, 1469–1495 (2021). https://doi.org/10.1007/s00044-021-02748-z

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