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How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy

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Abstract

Toll-like receptors (TLR)s are central in immune response by recognizing pathogen-associated molecular patterns (PAMP)s. If they are essential to eliminate pathogens in earlier stages of infection, they also might play a role in homeostasis and tissue repair. TLR versatility parallels the plasticity of monocytes, which represent an heterogeneous population of immune cells. They are rapidly recruited to sites of infection and involved in clearance of pathogens and in tissue healing. This review underlines how TLRs have proved to be an interesting tool to study the properties of monocytes and why different therapeutic strategies exploring monocyte plasticity may be relevant in the context of chronic inflammatory disorders.

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  1. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Pampulha, Belo Horizonte, MG, 31270-910, Brazil

    Catherine Ropert

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Ropert, C. How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy. Cell. Mol. Life Sci. 76, 745–755 (2019). https://doi.org/10.1007/s00018-018-2959-9

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