Sequence and protein alignments of the natural and QTY variants of seven monoamine transporters.
The specific alignments are as follows: a NET vs NETQTY, b DAT vs DATQTY, c SERT vs SERTQTY, d VMAT1 vs VMAT1QTY, e VMAT2 vs VMAT2QTY, f VAChT vs VAChTQTY, and g VPAT vs VPATQTY. Molecular weight and isoelectric point (pI) are listed for both the natural and QTY variants. The transmembrane variation percentage and total variation percentage between the natural and QTY variants are also provided. TM alpha-helices (in blue) displayed above the protein sequences and QTY amino acid substitution changes colored in red. Additional color coding is used to distinguish intracellular regions (yellow line), transmembrane helices (blue wave) and extracellular regions (pinkish line). Single-letter abbreviations for the amino acid residues: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, lle; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
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