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  • Academic researcher, systems scientist, editor, essayist, cultural critic and storyteller on planetary health, politi... moreedit
Public engagement in science is frequently sought after by a wide range of actors such as research funders, technology assessment agencies, scientists, policymakers, and patients. A key expectation is that public engagement will allow for... more
Public engagement in science is frequently sought after by a wide range of actors such as research funders, technology assessment agencies, scientists, policymakers, and patients. A key expectation is that public engagement will allow for new technologies to align with societal values, be socially just and broadly relevant to patients, and help democratize the means and the ends of scientific knowledge production.

In a recent analysis, Manahan and Kumar (2021) have noted the emerging shift from multilateralism to multistakeholderism in global governance, which has implications for hyperinstrumentalism in scientific practice.

The transactional turn in global governance by way of multistakeholderism is worthy of reflection to ensure that public engagement in science is critically informed on its means and the ends it serves at multiple scales, in the nation-state, global governance, and international relations.

https://www.liebertpub.com/doi/10.1089/omi.2022.0190
Predictive, Personalized, Preventive, and Participatory (P4) Medicine is embedded in the precision medicine conceptual framework to achieve the overarching goal of “the right drug, for the right patient, at the right dose, and at the... more
Predictive, Personalized, Preventive, and Participatory (P4) Medicine is embedded in the precision medicine conceptual framework to achieve the overarching goal of “the right drug, for the right patient, at the right dose, and at the right time.”

Science cultures and political determinants of health have normative and instrumental impacts on P4 medicine. Yet, since the age of Enlightenment in the 17th century, science and economics have been disarticulated from politics along the lines of classical liberalism, and with an ahistorical approach that continues into the 21st century. The consequence of this liberal disarticulation is that science is falsely and narrowly understood as an invariably technocratic and objective field. In the aftermath of the Covid-19 pandemic, it is clearer that political determinants of health are the causes-of-causes for disease and health.

I propose in this paper that we need P5 medicine with a fifth P, political determinants of planetary health. The new “P” can engage not only with instrumental aspects of P4 medicine research and clinical implementation but also with the structural factors that are an integral part of the politics of the P4 medicine. For example, the living legacies of colonialism contribute to the unequal relationships in trade, labor, provision, and production of materials among nation-states and between the Global South and the Global North and shape the class struggles in contemporary society, science, and medicine. A decolonial politics of care in which the political determinants of planetary health are taken seriously is therefore crucial and relevant to building a robust, ethical, responsible, and just P5 medicine in the 21st century.

https://www.liebertpub.com/doi/10.1089/omi.2023.0276
Why are some technologies and scientific fields more popular than others? This question has several answers that shed light on the complex ways in which glycomics and glycan-based diagnostics are currently emerging in personalized... more
Why are some technologies and scientific fields more popular than others? This question has several answers that shed light on the complex ways in which glycomics and glycan-based diagnostics are currently emerging in personalized medicine and systems science.

A socio-material conceptual lens brings together the long isolated scholarships on material and social dimensions of technology. The personalized medicine community stands to benefit from the concept of socio-materiality, so the “sugar lag” in diagnostics innovation can be remedied in an overarching vision of multi-omics scholarship and responsible innovation.

https://www.liebertpub.com/doi/10.1089/omi.2019.0223
Research Interests:
Obtaining an accurate and complete picture of patients’ experiences beyond the doctor’s office and health care settings is a current challenge and hot topic to enhance the precision of biomarker–phenotype association studies. Hence, the... more
Obtaining an accurate and complete picture of patients’ experiences beyond the doctor’s office and health care settings is a current challenge and hot topic to enhance the precision of biomarker–phenotype association studies. Hence, the focus of innovation strategy is broadening from increasing study sample sizes to deep phenotyping in the postgenomic era. To this end, phenomics is the systematic measurement and analysis of qualitative and quantitative traits, including clinical, biochemical, and imaging methods, for the refinement and characterization of a phenotype.

The recent rise of digital health and planetary scale digital connectivity offers prospects to measure real-world patient outcomes, in real time, and importantly, beyond a single or discrete time point in the course of a disease or drug treatment. Continuous measures allow us to decipher what patients experience fully, day time versus night time, at work versus at home, or in the living room versus walking down the stairs.

If we aim to develop diagnostics that stand the test of diverse real-world settings in which patients live, the contextualization of phenotype data across time and space is crucial. Real-time data capture is also important to prevent the participants’ recall bias in clinical trials and for complete phenotype characterization.

A new concept and term, the Internet of Pharmaceutical Things (IoPT), is necessary and timely to address precisely this gap at the intersection of the IoT and drugs/pharmaceuticals.

At its core, the IoPT represents further specialization of the IoT in drugs-related knowledge domain. Importantly, the IoPT fuses process innovation with experience innovation in how we capture phenotype data. With sensors embedded in diverse real-life settings (e.g., a smart wristwatch), the high-throughput required to capture patients’ experiences in scale, and in ways resolved in time and space, the IoPT architecture should bring about a hitherto missing real-life context to phenotyping of drug response and side effects.

https://doi.org/10.1089/omi.2020.0015
Digital health is a rapidly emerging field that offers several promising potentials: health care delivery remotely, in urban and rural areas, in any time zone, and in times of pandemics and ecological crises. Digital health encompasses... more
Digital health is a rapidly emerging field that offers several promising potentials: health care delivery remotely, in urban and rural areas, in any time zone, and in times of pandemics and ecological crises. Digital health encompasses electronic health, computing science, big data, artificial intelligence, and the Internet of Things, to name but a few technical components. Digital health is part of a vision for systems medicine. The advances in digital health have been, however, uneven and highly variable across communities, countries, medical specialties, and societal contexts. This article critically examines the determinants of digital health (DDH). DDH describes and critically responds to inequities and differences in digital health theory and practice across people, places, spaces, and time. DDH is not limited to studying variability in design and access to digital technologies. DDH is situated within a larger context of the political determinants of health. Hence, this article presents an analysis of DDH, as seen through political science, and the feminist studies of technology and society. A feminist lens would strengthen systems-driven, historically and critically informed governance for DDH. This would be a timely antidote against unchecked destructive/extractive governance narratives (e.g., technocracy and patriarchy) that produce and reproduce the health inequities.

Moreover, feminist framing of DDH can help cultivate epistemic competence to detect and reject false equivalences in how we understand the emerging digital world(s).

False equivalence, very common in the current pandemic and post-truth era, is a type of flawed reasoning in decision-making where equal weight is given to arguments with concrete material evidence, and those that are conjecture, untrue, or unjust.

A feminist conceptual lens on DDH would help remedy what I refer to in this article as “the normative deficits” in science and technology policy that became endemic with the rise of neoliberal governance since the 1980s in particular. In this context, it is helpful to recall the feminist writer Ursula K. Le Guin. Le Guin posed “what if?” questions, to break free from oppressive narratives such as patriarchy and re-imagine technology futures. It is time to envision an emancipated, equitable, and more democratic world by asking “what if we lived in a feminist world?” That would be truly awesome, for everyone, women and men, children, youth, and future generations, to steer digital technologies and the new field of DDH toward broadly relevant, ethical, experiential, democratic, and socially responsive health outcomes.

https://www.liebertpub.com/doi/10.1089/omi.2021.0020
Research Interests:
This paper takes an 'Epistemic X-ray' of the neoliberal knowledge economies in an era of climate emergency, and unpacks the infinite growth metanarrative of neoliberal production and promises for prosperity, health and wealth. The paper... more
This paper takes an 'Epistemic X-ray' of the neoliberal knowledge economies in an era of climate emergency, and unpacks the infinite growth metanarrative of neoliberal production and promises for prosperity, health and wealth. The paper situates 'epistemic safety' as a veritable site of contemporary struggle, solidarity and liberation in relation to climate emergency, planetary health and late capitalism.

https://www.liebertpub.com/doi/10.1089/omi.2024.0003

“The master’s tools will never dismantle the master’s house.”
- Audre Lorde (Lorde, 1983)
An analysis of the ways in which digital health innovations are being co-produced by mainstreaming of artificial intelligence (AI), the Internet of Things (IoT), and cyber-physical systems (CPS) in healthcare. CPS blurs the boundaries... more
An analysis of the ways in which digital health innovations are being co-produced by mainstreaming of artificial intelligence (AI), the Internet of Things (IoT), and cyber-physical systems (CPS) in healthcare.

CPS blurs the boundaries between the physical and virtual worlds, and creates a dynamic digital map of all things in existence that can be analyzed in ways that are much more sophisticated than a bar code scanning system.

Examples of CPS include self-driving cars, wearables for digital monitoring of heart arrhythmias, industrial AI powered robots in smart factories and health robots delivering home care services to disabled persons and rural communities. Another interesting prospect of digital health powered by AI, IoT and CPS is remote phenotypic data capture and characterization of pharmaceutical outcomes in clinical trials in ways that are user-centric and meaningful to patients. For rural or remote communities with limited access to medical product information, the IoT could bring about pharmacy and health services innovation.

There are unprecedented societal challenges at intersections of digital health with AI, IoT and CPS as well. For example, the physical and virtual worlds markedly differ in speed, scale and temporalities, as do our physical self and digital footprints. Our efforts to map and develop effective solutions to societal corollaries of AI, IoT and CPS need to bear in mind such asymmetries between the physical and virtual worlds. A societal issue such as privacy may emerge in different forms and intensities in the physical and virtual contexts. Digital data are highly fluid and can rapidly move across spaces and places whereas the physical data and humans are much slower and exist in different scales than our digital footprints.

https://www.liebertpub.com/doi/10.1089/omi.2019.0069
Research Interests:
Narratives are a veritable type of metadata. Narratives are power-laden storylines that conjure up emotions and enact value systems that markedly affect scientific practices, and to what ends, and for whom science and health innovations... more
Narratives are a veritable type of metadata. Narratives are power-laden storylines that conjure up emotions and enact value systems that markedly affect scientific practices, and to what ends, and for whom science and health innovations are made available. Narratives, if they are left unchecked, can undermine critical thinking and the agency of publics, threatening the possibilities for robust, responsible, relevant, and democratic science. One such narrative, a sociotechnical metadata in its own right, and of immense relevance in the current historical moment of the pandemic, is the uncritical use of the war and other military metaphors in COVID-19 science and planetary health interventions. In October 2022 issue of OMICS, Ebru Yetişkin adopts a biophilosophical transdisciplinary approach and feminist versions of science and technology studies to examine the ways in which the war discourse and other military metaphors have been deployed for the sake of biopower during COVID-19. In this article, we discuss the need to critically unpack the narrative metadata to leave the war metaphor behind, and hold to account the control tactics of biopower embedded in the COVID-19 pandemic.
Responsible innovation is an emerging social movement, concept and practice in governance of science and technology. Yet, responsible innovation cannot be fully understood without its historical origins and the gravitational pulls that... more
Responsible innovation is an emerging social movement, concept and practice in governance of science and technology. Yet, responsible innovation cannot be fully understood without its historical origins and the gravitational pulls that are impacting its development. Responsible innovation is emerging against a backdrop of: (1) bioethics scholarship that has been transformed over the past two decades such that a major wing of the discipline has adopted a utilitarian science enabler functionalist role situated in immediate proximity (and perhaps too close) to the science and technology actors; and (2) the field of science and technology studies (STS), which has traditionally offered critical insights into the backstage of science and technology, deconstructing the ways in which context, power and politics play an ever-present role in scientific knowledge co-production.

In this chapter I propose that for responsible innovation to evolve in a manner that is as socially responsive and responsible as the science it seeks to shape, a new epistemic layer of inquiry should be added, termed ethics-of-ethics. Recognition of ethics-of-ethics would foster greater reflexivity on the importance of processes of knowing, not only in natural science and technology, but also in social sciences and humanities. Such nested governance and independent cross-checking of knowledge co-production in both science and ethics would ensure that scientist, social scientist, humanists and ethicist are held accountable through transparency, for example, in the epistemological choices made, the upstream agendas created and the ends to which socio-technical analyses are intended to serve.

https://www.elgaronline.com/view/edcoll/9781784718855/9781784718855.00011.xml


DOI: https://doi.org/10.4337/9781784718862.00011
Science is not an activity executed by value-free machines, but by human beings with values and politics. A feminist lens on and queering of science, technology and innovation critically unpack and interrupt social injustices, unchecked... more
Science is not an activity executed by value-free machines, but by human beings with values and politics. A feminist lens on and queering of science, technology and innovation critically unpack and interrupt social injustices, unchecked assumptions, and blind spots in science and society, and opens up new, more democratic, ways of seeing and being in the worlds we inhabit. As an example, I adopt here the definition of feminism of the late cultural critic bell hooks because her works underscore that feminism is an intersectional liberatory methodology for everyone to resist multiple forms of oppression simultaneously.

Queer theory is a strand of social theory that came to prominence since the 1990s in particular. Queer feminism continues to shape feminist writing on science cultures and the knowledge-based innovations contemporary science strives to accomplish.

Systems science brings about systems thinking, and that includes rethinking science as culture beyond a narrow realm of technology, and being cognizant of the broader social, feminist, queer and political contexts of science around the world.

https://www.liebertpub.com/doi/10.1089/omi.2023.0216
Research Interests:
“The truth is rarely pure and never simple.” —Oscar Wilde (1854–1900) Lies and disinformation have always existed throughout human history. However, disinformation has become a “pandemic within a pandemic” with convergence of... more
“The truth is rarely pure and never simple.”

—Oscar Wilde (1854–1900)

Lies and disinformation have always existed throughout human history. However, disinformation has become a “pandemic within a pandemic” with convergence of COVID-19 and digital transformation of health care, climate emergency, and pervasive human–computer interaction in all facets of life. We are living through an era of post-truth. New approaches to fight disinformation are urgently needed and of paramount importance for systems science and planetary health.

In this study, we discuss the ways in which extractive and entrenched epistemologies such as technocracy and neoliberalism co-produce disinformation. We draw from the works of David Collingridge in technology entrenchment and the literature on digital health, international affairs, climate emergency, degrowth, and decolonializing methodologies.

We expand the vocabulary on and interventions against disinformation, and propose the following: (1) rapid epistemic disobedience as a critical governance tool to resist the cultural hegemony of neoliberalism and its master narrative infinite growth that is damaging the planetary ecosystems, while creating echo chambers overflowing with disinformation, and (2) a two-tiered taxonomy of reflexivity, a state of self-cognizance by knowledge actors, for example, scientists, engineers, and physicians (type 1 reflexivity), as well as by chroniclers of former actors, for example, civil society organizations, journalists, social sciences, and humanities scholars (type 2 reflexivity).

This article takes seriously the role of master narratives in quotidian life in production of disinformation and ecological breakdown. The infinite growth narrative does not ask critical questions such as “growth in what, at what costs to society and environment?,” and is a dangerous game of brinkmanship that has been testing the planetary ecological boundaries and putting at risk the veracity of knowledge. There is a need for scholars and systems scientists who break ranks with entrenched narratives that pose existential threats to planetary sustainability and are harmful to knowledge veracity. Scholars who resist the obvious recklessness and juggernaut of the pursuit of neoliberal infinite growth would be rooting for living responsibly and in solidarity on a planet with finite resources. The interventions proposed in this study, rapid epistemic disobedience and the expanded reflexivity taxonomy, can advance progressive policies for a good life for all within planetary boundaries, and decolonize knowledge from disinformation in ways that are necessarily upstream, radical, rapid, and emancipatory.

https://www.liebertpub.com/doi/10.1089/omi.2022.0041
Research Interests:
The number of wirelessly connected smart objects, excluding smartphones and computers, reached 8.4 billion worldwide by the end of 2017. The Intel forecasts that there will be more than 200 billion wirelessly connected objects by 2020,... more
The number of wirelessly connected smart objects, excluding smartphones and computers, reached 8.4 billion worldwide by the end of 2017. The Intel forecasts that there will be more than 200 billion wirelessly connected objects by 2020, which means more than 25 smart objects per person on the planet. The Internet of Things (IoT) and cyber-physical systems (CPS) refer to this pervasive computing environment that is producing a digital replica of all living things and inanimate objects across the planet. The IoT and CPS are transforming how scientific knowledge and innovations are produced and embedded in the society. If we add the capability of real-time data analysis with artificial intelligence (AI), we have powerful new tools for applications in genomics, system sciences, and public health. Some of the conceivable applications of IoT, CPS, and AI include, for example, real-time remote phenotypic data capture, genotype–phenotype association analyses, and multiomics data integration.

The chapter presents a socio-technical analysis of extreme digital connectivity, IoT, CPS, and AI that are playing ever-increasing roles in system science innovations and society. In addition, I highlight the current “AI turn” for genomics, and the emerging need for anticipatory and critically informed approaches to next-generation innovation policy.

https://www.sciencedirect.com/science/article/pii/B9780128136959000157?via%3Dihub
Research Interests:
Loss of biodiversity has manifold negative impacts on health, for example, rise of zoonotic infections and changes in healthy microbiome. But reducing our ecological footprints is not enough. We ought to change mindsets, the narrow... more
Loss of biodiversity has manifold negative impacts on health, for example, rise of zoonotic infections and changes in healthy microbiome. But reducing our ecological footprints is not enough. We ought to change mindsets, the narrow science, and technology governance regimes that value nature and other life forms instrumentally by their usefulness to us. This paper describes three new, broader and critically-informed, frames on governance for  planetary  health.

https://www.liebertpub.com/doi/full/10.1089/omi.2019.0175

https://www.liebertpub.com/doi/epdf/10.1089/omi.2019.0175
Research Interests:
An alien visitor to planet Earth reading the contemporary textbooks on diagnostics might think precision medicine requires only two biomolecules omnipresent in the literature: nucleic acids (e.g., DNA) and proteins, known as the first and... more
An alien visitor to planet Earth reading the contemporary textbooks on diagnostics might think precision medicine requires only two biomolecules omnipresent in the literature: nucleic acids (e.g., DNA) and proteins, known as the first and second alphabet of biology, respectively. However, the precision/personalized medicine community has so far underappreciated the third alphabet of life, the “sugar code” (i.e., the information stored in glycans, glycoproteins, and glycolipids).

This article examines the ways in which contemporary debates and values around the third alphabet of life are shaped by history and politics of the sugar code, and the socio-materiality of the cell.
Research Interests:
Diversity is increasingly at stake in early 21st century. Diversity is often conceptualized across ethnicity, gender, socioeconomic status, sexual preference, and professional credentials, among other categories of difference. These are... more
Diversity is increasingly at stake in early 21st century. Diversity is often conceptualized across ethnicity, gender, socioeconomic status, sexual preference, and professional credentials, among other categories of difference. These are important and relevant considerations and yet, they are incomplete.

Diversity also rests in the way we frame questions long before answers are sought.

Such diversity in the framing (epistemology) of scientific and societal questions is important for they influence the types of data, results, and impacts produced by research. Errors in the framing of a research question, whether in technical science or social science, are known as type III errors, as opposed to the better known type I (false positives) and type II errors (false negatives). Kimball defined “error of the third kind” as giving the right answer to the wrong problem. Raiffa described the type III error as correctly solving the wrong problem. Type III errors are upstream or design flaws, often driven by unchecked human values and power, and can adversely impact an entire innovation ecosystem, waste money, time, careers, and precious resources by focusing on the wrong or incorrectly framed question and hypothesis. Decades may pass while technology experts, scientists, social scientists, funding agencies and management consultants continue to tackle questions that suffer from type III errors.

We propose a new diversity metric, the Frame Diversity Index (FDI), based on the hitherto neglected diversities in knowledge framing. The FDI would be positively correlated with epistemological diversity and technological democracy, and inversely correlated with prevalence of type III errors in innovation ecosystems, consortia, and knowledge networks. We suggest that the FDI can usefully measure (and prevent) type III error risks in innovation ecosystems, and help broaden the concepts and practices of diversity and inclusion in science, technology, innovation and society.

https://www.liebertpub.com/doi/10.1089/omi.2018.0002
One nature aims to transcend the socially constructed binaries between humans versus nature, humans versus nonhuman animals or inanimate objects in nature, amongst other false binaries, and thus, envisions nature as an overlapping,... more
One nature aims to transcend the socially constructed binaries between humans versus nature, humans versus nonhuman animals or inanimate objects in nature, amongst other false binaries, and thus, envisions nature as an overlapping, interdependent and co-constitutive continuum among life forms and ecosystems. One nature also recognizes animal sentience and agency of nonhuman animals. In doing so, the one nature governance frame places a firm emphasis on the internal levers of social change and the human values essential to cultivate collective action to curb unchecked extraction of nature that placed human societies in harm’s way for future health crises.

One nature is a governance frame and reflexive value system that can be transformative to correct the astigmatism we have long suffered, from the ways in which we have conceived, enacted on, and extracted the natural systems over the centuries. All in all, one nature supports planetary health and biodiversity through a new vocabulary and post-anthropocentric critical governance lens, and shall help formulate progressive policies to prevent zoonotic outbreaks and future ecological crises.

https://www.liebertpub.com/doi/10.1089/omi.2020.0169
Research Interests:
The COVID-19 pandemic is an epic calamity. It also has a silver lining. Amid the crisis, communities around the world are contemplating on hard lessons about fragility of life, existential threats, and the importance of thinking beyond... more
The COVID-19 pandemic is an epic calamity. It also has a silver lining. Amid the crisis, communities around the world are contemplating on hard lessons about fragility of life, existential threats, and the importance of thinking beyond the socially constructed binary of humans versus nature. The unchecked human power on nature is a factor feeding the rise of zoonotic infection outbreaks in the first quarter of the 21st century, with microorganisms jumping from their animal hosts to humans.

Ecological crises can be prevented or their adverse impacts reduced by establishing planetary public goods (PPGs), as anticipatory responses to pandemics, climate change, and other crises looming on the horizon. A prominent lesson emerging from the COVID-19 pandemic is that planetary health care, vaccines, essential medicines, and personal protective equipment ought to be PPGs. This is important for both instrumental and normative reasons as described in this article.

https://www.liebertpub.com/doi/pdfplus/10.1089/omi.2020.0118
We have much work to do for diversity and democracy in Science, Technology, Engineering, and Mathematics (STEM) fields worldwide. We need to think beyond heteronormativity and the gender binary, so transgender, nonbinary and 2SLGBTQ+... more
We have much work to do for diversity and democracy in Science, Technology, Engineering, and Mathematics (STEM) fields worldwide. We need to think beyond heteronormativity and the gender binary, so transgender, nonbinary and 2SLGBTQ+ scientists are well represented in science, health research and society. To live into the promise of equity, the desire for diversity and inclusion must mean more than simply shuffling a stacked deck so that we might draw a better hand. Instead, we must be willing to do the difficult work of questioning and unpacking the game itself so that we are better positioned to rewrite its rules.

https://www.liebertpub.com/doi/10.1089/omi.2022.0059
Lies and disinformation have always existed throughout human history. However, disinformation has become a “pandemic within a pandemic” with convergence of COVID-19 and digital transformation of health care, climate emergency, and... more
Lies and disinformation have always existed throughout human history. However, disinformation has become a “pandemic within a pandemic” with convergence of COVID-19 and digital transformation of health care, climate emergency, and pervasive human–computer interaction in all facets of life. We are living through an era of post-truth. New approaches to fight disinformation are urgently needed and of paramount importance for systems science and planetary health. In this study, we discuss the ways in which extractive and entrenched epistemologies such as technocracy and neoliberalism co-produce disinformation. We draw from the works of David Collingridge in technology entrenchment and the literature on digital health, international affairs, climate emergency, degrowth, and decolonializing methodologies. We expand the vocabulary on and interventions against disinformation, and propose the following: (1) rapid epistemic disobedience as a critical governance tool to resist the cultural hegemony of neoliberalism and its master narrative infinite growth that is damaging the planetary ecosystems, while creating echo chambers overflowing with disinformation, and (2) a two-tiered taxonomy of reflexivity, a state of self-cognizance by knowledge actors, for example, scientists, engineers, and physicians (type 1 reflexivity), as well as by chroniclers of former actors, for example, civil society organizations, journalists, social sciences, and humanities scholars (type 2 reflexivity). This article takes seriously the role of master narratives in quotidian life in production of disinformation and ecological breakdown. The infinite growth narrative does not ask critical questions such as “growth in what, at what costs to society and environment?,” and is a dangerous game of brinkmanship that has been testing the planetary ecological boundaries and putting at risk the veracity of knowledge. There is a need for scholars and systems scientists who break ranks with entrenched narratives that pose existential threats to planetary sustainability and are harmful to knowledge veracity. Scholars who resist the obvious recklessness and juggernaut of the pursuit of neoliberal infinite growth would be rooting for living responsibly and in solidarity on a planet with finite resources. The interventions proposed in this study, rapid epistemic disobedience and the expanded reflexivity taxonomy, can advance progressive policies for a good life for all within planetary boundaries, and decolonize knowledge from disinformation in ways that are necessarily upstream, radical, rapid, and emancipatory.
Research Interests:
Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included,... more
Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included, emphasize the speed as the prevailing ideology.

But a narrow focus on speed has several and overlooked shortcomings in science governance and technology policy.
We are submerged in a sea of Big Data, AI, and extreme digital connectivity at an unprecedented planetary scale, creating what has been recently termed the ‘‘Quantified Planet’’. But in the current AI and automation gold rush, we might... more
We are submerged in a sea of Big Data, AI, and extreme digital connectivity at an unprecedented planetary scale, creating what has been recently termed the ‘‘Quantified Planet’’. But in the current AI and automation gold rush, we might also be drifting away from human intelligence (HI).

If we are to harness the new technologies for robust, reproducible, and responsible innovation in biology and medicine, we need data science, automation, and AI working in tandem with HI, and so that they serve science and society, rather than vice versa.

https://www.liebertpub.com/doi/10.1089/omi.2019.0003
Research Interests:
A brief history of how personalized/precision medicine emerged as a fringe academic curiosity and became a part of mainstream clinical medicine.

https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/S0009-9236%2899%2970006-8
This paper provides (1) a history of placebo from 13th century onward, (2) an analysis on biology, mechanisms and variability of placebo effects, and (3) three emerging new concepts: placebogenomics, nocebogenomics and augmented placebo,... more
This paper provides (1) a history of placebo from 13th century onward, (2) an analysis on biology, mechanisms and variability of placebo effects, and (3) three emerging new concepts: placebogenomics, nocebogenomics and augmented placebo, i.e., the notion of a “placebo dose”.

We conclude with a roadmap for placebogenomics, its synergies with the nascent field of social pharmacology, and the ways in which a new taxonomy of drug and placebo variability can be anticipated in the next decade.

https://www.liebertpub.com/doi/10.1089/omi.2020.0208
Research Interests:
The current paradigm of drug development can detect only the most common Adverse Drug Reactions (ADRs) during clinical trials. One reason is that new drug candidates are tested in as few as 500 and rarely >5000 individuals in clinical... more
The current paradigm of drug development can detect only the most common Adverse Drug Reactions (ADRs) during clinical trials. One reason is that new drug candidates are tested in as few as 500 and rarely >5000 individuals in clinical trials. Once a drug is set free for use outside the realm of controlled clinical trials, novel ADR signals begin to emerge as the diversity and size of the population exposed to the drug increase to many thousands and millions.

Could the existing pharmacovigilance paradigm be improved to detect a broader range of ADRs, including those that are uncommon, and well in advance of deploying new drugs in clinical practice?

https://www.liebertpub.com/doi/10.1089/omi.2019.0013
Clozapine is an atypical antipsychotic drug and displays efficacy in 30% to 60% of patients with schizophrenia who do not respond to traditional antipsychotics. A clozapine concentration greater than 1,150 nmol/L increases the probability... more
Clozapine is an atypical antipsychotic drug and displays efficacy in 30% to 60% of patients with schizophrenia who do not respond to traditional antipsychotics. A clozapine concentration greater than 1,150 nmol/L increases the probability of antipsychotic efficacy. However, plasma clozapine concentration can vary more than 45-fold during long-term treatment. The aim of this study was to assess the contribution of CYP1A2 to variability in steady-state concentration of clozapine and its active metabolite norclozapine. Patients with schizophrenia or schizoaffective disorder were prospectively monitored during clozapine treatment (N = 18). The in vivo CYP1A2 activity was measured using the caffeine metabolic ratio (CMR) in overnight urine. Trough plasma samples were drawn after at least 5 days of treatment with a constant regimen of clozapine. A significant negative association was found between the CMR and the dose-corrected clozapine (r(s) = -0.87,p < 0.01) and norclozapine (r(s) = -0.76,p < 0.01) concentrations. Nonsmokers displayed a higher clozapine (3.2-fold) and norclozapine (2.3-fold) concentration than smokers (p < 0.05). Furthermore, there was marked person-to-person variation in CYP1A2 activity during multiple-dose clozapine treatment (coefficient of variation = 60%). Age, weight, serum creatinine, and grapefruit juice consumption did not significantly contribute to variability in clozapine and norclozapine concentration (p > 0.05). In conclusion, CYP1A2 is one of the important contributors to disposition of clozapine during multiple-dose treatment. Although further in vitro experiments are necessary, the precise metabolic pathways catalyzed by CYP1A2 seem to be subsequent to the formation of norclozapine, hitherto less recognized quantitatively important alternate disposition routes, or both. From a clinical perspective, an environmentally induced or constitutively high CYP1A2 expression can lead to a decrease in steady-state concentration of clozapine as well as its active metabolite norclozapine. Thus, interindividual variability in CYP1A2 activity may potentially explain treatment resistance to clozapine in some patients. CYP1A2 phenotyping with a simple caffeine test may contribute to individualization of clozapine dosage and differentiate between treat ment noncompliance and high CYP1A2 activity.
Approximately one in two patients with a chronic disease does not take their medicines as prescribed. Poor adherence is a worldwide epidemic and a major source of variability in pharmacokinetics (PK) and pharmacodynamics. Without... more
Approximately one in two patients with a chronic disease does not take their medicines as prescribed. Poor adherence is a worldwide epidemic and a major source of variability in pharmacokinetics (PK) and pharmacodynamics. Without addressing adherence, precision medicine is unlikely to come to fruition. In drug development, poor adherence confounds the estimates for efficacy and safety of drug candidates. Accurate and high-resolution measurement of adherence is a first step toward effective interventions against poor adherence. We describe a new cross-technology platform to measure adherence.

The approach involves, first, building PK models to explain dose-exposure relationships. The model incorporates PK biomarkers by genotyping or phenotyping of drug metabolism, transport and other drug clearance pathways. Importantly, dose-exposure data for model building are obtained in healthy volunteer and/or patient cohorts who are ascertained for full adherence, using edible ingestion sensors (IS) that digitize orally administered medicines. Second, the built model is harnessed to back calculate the dose actually ingested by patients, given the empirically observed drug exposure, PK biomarker, demographic, and other patient data.

The proposed platform is envisioned to result in development of both drug and drug-specific companion software for adherence measurement. In terms of feasibility, the new approach overlaps with current drug development timelines spanning the Phase 1 to 4 clinical trial continuum, and thus, could conceivably be implemented without requiring significant changes to the time sensitive clinical trial processes. For the IS-powered tools, the proposed platform creates a new space for applications in clinical trials to ensure adherence.

https://www.liebertpub.com/doi/10.1089/omi.2019.0092
Personalized medicine and clinical pharmacology are currently in a watershed moment as they undergo digital transformation with planetary scale digital connectivity.

https://doi.org/10.1089/omi.2020.0035
The COVID-19 pandemic by the new coronavirus is evolving and wreaking havoc across the planet at the time of the writing of this editorial for the OMICS special issue on digital health. For the past three months, many institutions and... more
The COVID-19 pandemic by the new coronavirus is evolving and wreaking havoc across the planet at the time of the writing of this editorial for the OMICS special issue on digital health. For the past three months, many institutions and countries have focused their science on COVID-19 to develop new vaccines and drugs. Although emergency and intensive medical care are essential more than ever, digital health has also become a cornerstone of the collective response to the pandemic as people stay at home and practice social distancing.

The OMICS special issue addresses the current rise of digital health. It is a subject that is relevant for 21st century health care as well as for addressing the unprecedented challenges of the COVID-19 pandemic.

Full text available at: https://www.liebertpub.com/doi/pdf/10.1089/omi.2020.0049
Antipsychotic response to clozapine varies markedly among patients with schizophrenia. The disposition of clozapine is dependent, in part, on the cytochrome P-450 (CYP) 1A2 enzyme in vivo. In theory, a very high CYP1A2 activity may lead... more
Antipsychotic response to clozapine varies markedly among patients with schizophrenia. The disposition of clozapine is dependent, in part, on the cytochrome P-450 (CYP) 1A2 enzyme in vivo. In theory, a very high CYP1A2 activity may lead to subtherapeutic concentrations and treatment resistance to clozapine. This prospective case study evaluates the clinical significance of ultrarapid CYP1A2 activity and a recently discovered single nucleotide (C --> A) polymorphism in intron 1 of the CYP1A2 gene (CYP1A2*F) for treatment resistance to clozapine. In addition, we describe the effect of grapefruit juice or low-dose fluvoxamine (25-50 mg/d) coadministration on clozapine and active metabolite norclozapine steady-state plasma concentration and antipsychotic response.
Research Interests:
Research Interests:
Art and literature that ignite progressive social movements have a secret active ingredient: an enduring hope for change. We need radically new ways of thinking about and cultivating hope for progressive social change in the 21st... more
Art and literature that ignite progressive social movements have a secret active ingredient: an enduring hope for change.

We need radically new ways of thinking about and cultivating hope for progressive social change in the 21st century.

https://newpol.org/the-sociology-and-biology-of-radical-hope/
Hope is not optimism. In a time of authoritarian politics and the rise of oppressive governance regimes worldwide, it is time to rethink what hope is, and recognize the important role hope plays in shaping democracy and protecting... more
Hope is not optimism. In a time of authoritarian politics and the rise of oppressive governance regimes worldwide, it is time to rethink what hope is, and recognize the important role hope plays in shaping democracy and protecting minority rights.

http://www.agos.com.tr/en/article/21170/what-is-hope-in-a-time-of-global-populism-and-realpolitik
We have much work to do for diversity and democracy in Science, Technology, Engineering, and Mathematics (STEM) fields worldwide. We need to think beyond heteronormativity and the gender binary, so transgender, nonbinary and 2SLGBTQ+... more
We have much work to do for diversity and democracy in Science, Technology, Engineering, and Mathematics (STEM) fields worldwide. We need to think beyond heteronormativity and the gender binary, so transgender, nonbinary and 2SLGBTQ+ scientists are well represented in science, health research and society. To live into the promise of equity, the desire for diversity and inclusion must mean more than simply shuffling a stacked deck so that we might draw a better hand. Instead, we must be willing to do the difficult work of questioning and unpacking the game itself so that we are better positioned to rewrite its rules.

https://www.liebertpub.com/doi/10.1089/omi.2022.0059
Electoral political systems that are present in form, but without substance, “zombie democracies”, are major threats to global democracy. Zombie democracy is a very stark form of repression where periodic elections are still held but the... more
Electoral political systems that are present in form, but without substance, “zombie democracies”, are major threats to global democracy. Zombie democracy is a very stark form of repression where periodic elections are still held but the regime does not even pretend that elections are free or fair. A zombie democracy is “the living dead of electoral political systems, recognizable in form but devoid of any substance.”.

Zombie democracies are common. They occur in both the global North and global South. Populist autocrats often contribute to the making of zombie democracies. To fight zombie democracies, we should first unpack the psychology of populist autocrats. For example: how do populist autocrats think and feel? What wakes them up in the middle of the night? What insistently drives them to hold on to political power?

https://www.agos.com.tr/en/article/27431/to-fight-zombie-democracies-we-should-unpack-the-psychology-of-populist-autocrats-and-echo-chambers
There is growing worldwide acceptance and evidence for the idea that gender and sexual identity are not fixed but fluid and open-ended. Life is beautiful with love and democracy, and when we begin thinking beyond the gender and sexual... more
There is growing worldwide acceptance and evidence for the idea that gender and sexual identity are not fixed but fluid and open-ended. Life is beautiful with love and democracy, and when we begin thinking beyond the gender and sexual identity binaries.

https://www.duvarenglish.com/a-rainbow-for-everyone-news-58068
Echo chambers are bad for democracy and public health. This is precisely where the legacy of the late poet and artist Lawrence Ferlinghetti offers hope to open up echo chambers and build genuine democracies.... more
Echo chambers are bad for democracy and public health. This is precisely where the legacy of the late poet and artist Lawrence Ferlinghetti offers hope to open up echo chambers and build genuine democracies.

http://www.agos.com.tr/en/article/25656/ferlinghettis-legacy-the-freedom-outside-echo-chambers
Both scientists and journalists seek the truth. But the truth is caught between a rock and a hard place with COVID-19. We are facing, on the one hand, an anti-science movement and, on the other hand, scientific essentialism that omits the... more
Both scientists and journalists seek the truth. But the truth is caught between a rock and a hard place with COVID-19. We are facing, on the one hand, an anti-science movement and, on the other hand, scientific essentialism that omits the role of power politics and human values in the making of truth. As an antidote, we need a new narrative on evidence frameworks in journalism that expands on the classic 5W + 1H.

https://www.duvarenglish.com/opinion/2020/07/04/meet-the-new-minority-the-truth/
Digital technologies offer real prospects for health care in an era of COVID-19. But let’s not forget that health is ultimately analog. We have not become AI powered robots, at least not just yet. Digital health is a proxy, a tool, not an... more
Digital technologies offer real prospects for health care in an era of COVID-19. But let’s not forget that health is ultimately analog. We have not become AI powered robots, at least not just yet. Digital health is a proxy, a tool, not an end point, to improve analog health.

https://duvarenglish.com/health-2/2020/09/10/digital-health-futures-who-guards-the-guards/
We need poetry for hope against the tyranny of the autocrats. Times of populism and autocracy will pass but poetry will stay with us forever.

https://www.duvarenglish.com/resisting-fascism-with-hope-powered-by-poetry-news-55702
A smirk is invariably political and never innocent. Smirk undermines democratic practices and human rights. Let’s bear in mind that oppression is sometimes enacted upon us in the form of a smirk.... more
A smirk is invariably political and never innocent. Smirk undermines democratic practices and human rights. Let’s bear in mind that oppression is sometimes enacted upon us in the form of a smirk.

https://www.duvarenglish.com/opinion/2020/09/24/the-smirk-and-its-politics/
Turkey has reopened to a new normal on June 1. The new normal is a red herring; a smoke screen to manufacture consent to put unchecked political power, profits and wealth over health. There will be a greater risk for conflict in the next... more
Turkey has reopened to a new normal on June 1. The new normal is a red herring; a smoke screen to manufacture consent to put unchecked political power, profits and wealth over health. There will be a greater risk for conflict in the next 12 months in societies divided into haves and have-nots with the pandemic.

https://www.duvarenglish.com/opinion/2020/06/03/why-is-reopening-turkey-wrong-now/
We do not know the true scale of the COVID-19 pandemic in the world. When will it be safe to reopen schools, go back to work and daily life again? What if you already had the infection without symptoms, recovered and now immune?... more
We do not know the true scale of the COVID-19 pandemic in the world. When will it be safe to reopen schools, go back to work and daily life again? What if you already had the infection without symptoms, recovered and now immune? Widespread antibody blood testing can help answer these questions and should be developed and made broadly available, together with the current tests that detect the virus.

http://www.agos.com.tr/en/article/23857/coronavirus-antibody-test-for-truth-tracking
What would an ideal cure for COVID-19 look like, medically and sociologically? I suggest it should be a ‘two-in-one’ cure, (1) restoring human biology, and (2) reinstating trust in society, thus enabling collective action to stem the... more
What would an ideal cure for COVID-19 look like, medically and sociologically?

I suggest it should be a ‘two-in-one’ cure, (1) restoring human biology, and (2) reinstating trust in society, thus enabling collective action to stem the pandemic.

Such a solution might be available sooner than what the current dark clouds on the planet suggest. There are now growing numbers of COVID-19 survivors anticipated to have coronavirus-neutralizing antibodies in their blood. Administration of plasma obtained from consenting survivors’ blood can, potentially, make the recipients immune to coronavirus immediately, for a period that may last weeks or months. It can prevent healthy persons from getting the virus or help treat patients with COVID-19. This is particularly valuable to protect older people; nurses, physicians and laboratory technicians and thus help prevent the collapse of health systems; and those who care for friends and family sick with COVID-19 at home.

On March 19, an Investigational New Drug Application was filed with the United States Food and Drug Administration (FDA) by a team led by Dr. Arturo Casadevall at Johns Hopkins University in Baltimore for clinical testing of the human convalescent plasma. Results may be available as early as summer 2020. 

The convalescent plasma approach, if brought to life by early summer, will also have sociological effects. It will bring convalescent serum donors and recipients from diverse politics and walks of life together, potentially creating new solidarities and social dynamics. One can think of many examples in Turkey and elsewhere.

Of course, it is also conceivable that individuals, institutions and countries may attempt to sell the COVID-19 convalescent plasma as a commodity and at prohibitive prices, rather than seeing it as a public good to be shared by consenting persons for solidarity and mutual aid.

Still, on balance, the prospect of helping others through plasma donation might surely open up constructive spaces for new forms and formats of solidarity in historically entrenched and divided political landscapes.

https://www.duvarenglish.com/opinion/2020/03/26/the-plasma-of-covid-19-survivors-might-help-the-world-fight-coronavirus/
Politics of medicine is perhaps nowhere else more prominent than in the case of COVID-19 testing. To stem the new coronavirus pandemic, we ought to address both corona-science and corona-politics. We live in times of authoritarian,... more
Politics of medicine is perhaps nowhere else more prominent than in the case of COVID-19 testing. To stem the new coronavirus pandemic, we ought to address both corona-science and corona-politics.

We live in times of authoritarian, anti-intellectual populism. The late Hannah Arendt (1906-1975), an astute political theorist, has said “words can be relied on only if one is sure that their function is to reveal and not to conceal”. That calls for open, independent science, for COVID-19 testing.

Politics refers to constitution and contestation of power in society. There is ‘politics’ whenever there is a power asymmetry or a difference between ‘what is said’ and ‘what is actually happening’ in society. Even a smile can be political, if it is intended to exert influence and power on others.

Testing for COVID-19 is inherently political: the criteria for who should be tested, choice of the laboratory method, centralized or distributed testing, how the test results are reported, amongst other decisions.

https://www.duvarenglish.com/opinion/2020/03/16/the-science-and-politics-of-coronavirus/
The current outbreak by the new coronavirus 2019-nCoV is not the first, and will not be the last microbe that jumped from animals to humans, because we continue to eat animals as food and invade their natural territory. A good way to... more
The current outbreak by the new coronavirus 2019-nCoV is not the first, and will not be the last microbe that jumped from animals to humans, because we continue to eat animals as food and invade their natural territory. A good way to reduce infectious outbreaks from animals is veganism, stopping wildlife trade, human consumption of animal products, and importantly, recognizing animal sentience. Article 13 of the Lisbon Treaty in 2009 recognized animal sentience in Europe. We should follow suit because we are less likely to eat animals, colonize wildlife habitats and be exposed to animal pathogens, once we accept animal sentience and agency.

http://www.agos.com.tr/en/article/23573/embracing-veganism-and-animal-sentience-the-long-view-on-coronavirus-outbreak
The rise of populism and post-truth is a wake up call to humanity and modernity to: (1) Recognize that knowledge production, journalism (and life) are value-loaded, and thus, inherently political, (2) Rethink the relationship between... more
The rise of populism and post-truth is a wake up call to humanity and modernity to: (1) Recognize that knowledge production, journalism (and life) are value-loaded, and thus, inherently political, (2) Rethink the relationship between journalism and activism, (3) Realize it is not politics but sweeping politics under the carpet and unchecked human power that are existential threats to journalism, democracy and peace on planet Earth in the 21st century.

http://www.agos.com.tr/en/article/21777/the-fly-on-the-wall
One of the biggest challenges for refugees anywhere is finding quality medical care. To address this need, and to help reduce the burden that refugees place on host countries' health systems, efforts must be made to retrain and integrate... more
One of the biggest challenges for refugees anywhere is finding quality medical care. To address this need, and to help reduce the burden that refugees place on host countries' health systems, efforts must be made to retrain and integrate refugee doctors into the medical profession in their new homes.
The 2018 International Women’s Day campaign began on March 8 and will continue all year. The campaign is action oriented, and appropriately named #PressforProgress. But progress toward gender parity is not enough. The right question to... more
The 2018 International Women’s Day campaign began on March 8 and will continue all year. The campaign is action oriented, and appropriately named #PressforProgress.

But progress toward gender parity is not enough. The right question to ask is: How soon can we eliminate gender-based injustices completely?
This OP-ED introduces the term glyco-theranostics and defines it as an emerging scholarship on clinical, ecological and planetary health diagnostics and therapeutics informed by carbohydrates, glycan variation in particular, that offers... more
This OP-ED introduces the term glyco-theranostics and defines it as an emerging scholarship on clinical, ecological and planetary health diagnostics and therapeutics informed by carbohydrates, glycan variation in particular, that offers mechanistic explanations for intra- and inter-individual variations in outcomes of health interventions such as drugs, food, vaccines, and medical devices, amongst others.
Artificial intelligence (AI)-powered robots are being introduced for automation in healthcare, and on the street as facial recognition software. However, AI robots can only be as smart and democratic as the data we feed into their... more
Artificial intelligence (AI)-powered robots are being introduced for automation in healthcare, and on the street as facial recognition software. However, AI robots can only be as smart and democratic as the data we feed into their algorithms and the persons who use them. AI can also amplify the historical and social injustices embedded in data. For AI and robot ethics, let’s not forget it is us – humans with all our prejudices – and not aliens from space, who are designing and deploying AI robots in healthcare and society.
Women are the only minority group who are not a minority in number. Lack of equal rights, of power and autonomy, not a deficit in numbers, are what make certain groups of people a minority, excluding them from the dominant mainstream.... more
Women are the only minority group who are not a minority in number. Lack of equal rights, of power and autonomy, not a deficit in numbers, are what make certain groups of people a minority, excluding them from the dominant mainstream.

This brings us to the idea that in order for feminism and women’s rights to succeed, we need to start with our own children.

Raising feminist daughters will not suffice. We also need to raise feminist sons. If we are not a parent, we can also share some of these ideas with our best friend.

How can we raise a feminist son in the Middle East? I present here 5 ideas.
Research Interests:
Research Interests:
Research Interests:
While both velocity and veracity of innovation are important to the future of digital health, without veracity of big data, velocity would lose its meaning.
Մեզ անհրաժեշտ են արմատական յոյս եւ անդրազգային համերաշխութեան բոլորովին նոր գործելակերպներ՝ 21-րդ դարուն առաջադէմ ընկերական փոփոխութիւններու համար։... more
Մեզ անհրաժեշտ են արմատական յոյս եւ անդրազգային համերաշխութեան բոլորովին նոր գործելակերպներ՝ 21-րդ դարուն առաջադէմ ընկերական փոփոխութիւններու համար։

https://www.agos.com.tr/am/hvotvadzi/27691/armadagan-hvohsi-ingyerapanutiwni-ev-gyensapanutiwni
Pozitif beklentilerin beyin biyolojimize olan etkisi gibi, negatif beklentiler ve sosyal bağlamlar da (Örneğin otokratik bir ülkede veya sürgündeki bir sanatçıyı, gazeteciyi veya yazarı çevreleyen baskıcı politik ortam) vücut... more
Pozitif beklentilerin beyin biyolojimize olan etkisi gibi, negatif beklentiler ve sosyal bağlamlar da (Örneğin otokratik bir ülkede veya sürgündeki bir sanatçıyı, gazeteciyi veya yazarı çevreleyen baskıcı politik ortam) vücut fonksiyonlarını kötü yönde etkileyebilir. Bunlar plasebo etkisinin zıttı olan nosebonun bilinen etkileridir.

Agos Weekly 23.02.2024
Çeviri: Bared Çil

https://www.agos.com.tr/tr/yazi/29864/radikal-umudun-sosyolojisi-ve-biyolojisi-direnisin-yeni-sanatlari
Zombi demokrasi, seçimlerin periyodik olarak hala yapıldığı ancak rejimin artık seçimlerin özgür veya adilmiş gibi olduğunu bile göstermeye çalışmadığı, baskının en sert hallerinden biridir. Popülist otokratlar çoğunlukla zombi... more
Zombi demokrasi, seçimlerin periyodik olarak hala yapıldığı ancak rejimin artık seçimlerin özgür veya adilmiş gibi olduğunu bile göstermeye çalışmadığı, baskının en sert hallerinden biridir. Popülist otokratlar çoğunlukla zombi demokrasinin oluşmasında katkıda bulunurlar. Zombi demokrasilerle baş etmek için öncelikle popülist otokratların psikolojisini çözümlemeliyiz. Buna örnek olarak; Popülist otokratlar neler düşünür ve hissederler? Gecenin bir yarısı onları ne uyandırır? Israrla siyasi iktidara tutunmalarını sağlayan şey nedir? sorularını sorabiliriz.

https://www.agos.com.tr/tr/yazi/27461/zombi-demokrasilerle-bas-etmek
Hayat aşk ve demokrasiyle güzel, ikili cinsiyet kimliklerinin ötesinde düşünebilmeye başladığımızda daha da güzel olacak.

https://www.gazeteduvar.com.tr/herkese-bir-gokkusagi-demokratiklesme-ufuk-turu-1-haber-1549103
Dijital sağlıkta demokratikleşme ve ekolojik felaketlerle mücadele için, yeni yılda neoliberal teknoloji yönetişim çerçevelerinin dışında düşünmek elzem.... more
Dijital sağlıkta demokratikleşme ve ekolojik felaketlerle mücadele için, yeni yılda neoliberal teknoloji yönetişim çerçevelerinin dışında düşünmek elzem.

https://www.gazeteduvar.com.tr/dijital-saglik-ve-teknoloji-yonetisimi-demokratiklesme-ufuk-turu-2-haber-1549113
Yankı odaları hem demokrasi hem de halk sağlığı için zararlıdır. Geçtiğimiz Şubat ayında hayata veda eden şair ve sanatçı Lawrence Ferlinghetti'nin mirası, tam da bu noktada Türkiye'ye ve dünyaya yankı odalarını açmak ve gerçek... more
Yankı odaları hem demokrasi hem de halk sağlığı için zararlıdır. Geçtiğimiz Şubat ayında hayata veda eden şair ve sanatçı Lawrence Ferlinghetti'nin mirası, tam da bu noktada Türkiye'ye ve dünyaya yankı odalarını açmak ve gerçek demokrasiler inşa etmek için umut veriyor.

http://www.agos.com.tr/tr/yazi/25655/ferlinghettinin-mirasi-yanki-odalarinin-disindaki-ozgurluk
Otokratların tiranlığına karşı umut için, şiire ihtiyacımız var. Popülizm ve otokratlığın zamanı elbet geçecektir, ama şiir hep bizimle kalacak. https://www.gazeteduvar.com.tr/fasizme-siirin-umuduyla-direnmek-haber-1509102 We need... more
Otokratların tiranlığına karşı umut için, şiire ihtiyacımız var. Popülizm ve otokratlığın zamanı elbet geçecektir, ama şiir hep bizimle kalacak.

https://www.gazeteduvar.com.tr/fasizme-siirin-umuduyla-direnmek-haber-1509102

We need poetry for hope against the tyranny of the autocrats. Times of populism and autocracy will pass but poetry will stay with us forever.
Demokrasi sadece meclis ve senato gibi kurumlarda değil, gündelik hayat pratikleri içinde de nefes alır. Hayatın akışında karşılaştığımız eğri gülüş (smirk) daima politiktir ve asla masum değildir. Eğri gülüş demokrasiye ve insan... more
Demokrasi sadece meclis ve senato gibi kurumlarda değil, gündelik hayat pratikleri içinde de nefes alır. Hayatın akışında karşılaştığımız eğri gülüş (smirk) daima politiktir ve asla masum değildir. Eğri gülüş demokrasiye ve insan haklarına zarar verir. Baskı kendisini bazen alaycı bir tebessüm aracılığıyla kurar.

https://www.gazeteduvar.com.tr/egri-gulusun-politikasi-haber-1500562
Azınlık dediğimizde genellikle bir kişi veya topluluğu düşünürüz. Ancak bazen azınlık, belli bir görme biçimi de olabilir. 21. yüzyılda geldiğimiz noktada ise “hakikat”i yeni bir azınlık olarak tanımlayabilecek duruma geldik. Hem bilim... more
Azınlık dediğimizde genellikle bir kişi veya topluluğu düşünürüz. Ancak bazen azınlık, belli bir görme biçimi de olabilir. 21. yüzyılda geldiğimiz noktada ise “hakikat”i yeni bir azınlık olarak tanımlayabilecek duruma geldik.

Hem bilim insanları hem de gazeteciler hakikatin peşindedir. Ancak COVID-19’la birlikte hakikat iki eğilim arasında sıkışmış durumda. Bir yandan bilim karşıtı bir harekete, diğer yandan hakikati baskılayan iktidar politikalarını ve insan değerlerini inkar eden bir bilimsel özcülük anlayışına tanıklık ediyoruz.

Bilim karşıtlığı da bilimsel özcülük de hakikate ve kamu çıkarına zarar verir. COVID-19 salgınıyla her ikisinin de yükselişini izlemek mümkün.

https://www.gazeteduvar.com.tr/konuk-yazar/2020/07/17/yeni-bir-azinlik-hakikat/
Türkiye, 1 Haziran itibariyle “normalleşme” sürecine girdi. Bu “yeni normal”; kontrolsüz siyasi iktidarın, kârın ve servetin sağlığa tercih edildiği bir siyasaya rıza üretme işlevi gören bir göz bağıdır. Sosyal adaletsizliğe bir de... more
Türkiye, 1 Haziran itibariyle “normalleşme” sürecine girdi. Bu “yeni normal”; kontrolsüz siyasi iktidarın, kârın ve servetin sağlığa tercih edildiği bir siyasaya rıza üretme işlevi gören bir göz bağıdır. Sosyal adaletsizliğe bir de pandeminin eklenmesi, önümüzdeki 12 ay içerisinde çatışma riskini artırıyor.

https://www.gazeteduvar.com.tr/dunya-forum/2020/06/09/covid-19-ile-parasut-deneyi-turkiyede-su-an-normallesmeye-gecmek-neden-yanlis/
Her şeyin bir tarihi var. Bazı tarihler ise halktan gizlenir. Enfeksiyonlar da bunlara dahildir. Hükümetler teşhis testlerini kamu yararı yerine piyasa yararını gözeterek sınırladıklarında veya enfeksiyonların çoğunun klinik... more
Her şeyin bir tarihi var. Bazı tarihler ise halktan gizlenir. Enfeksiyonlar da bunlara dahildir.

Hükümetler teşhis testlerini kamu yararı yerine piyasa yararını gözeterek sınırladıklarında veya enfeksiyonların çoğunun klinik bulgularının hafif ve belirsiz olduğu durumlarda, salgınların gerçek boyutu ve yayılışının tarihi de karanlıkta kalmaya mahkumdur. COVID–19 örneğinde biri politik diğeri biyolojik kökenli bu her iki sorun da mevcut. Bu da hem Türkiye’de hem de dünyada salgına etkili ve demokratik bir karşılık verilmesinin önüne geçiyor.

Koronavirüs antikor testiyle gerçeğin izini sürmemiz mümkün. Böylece, COVID-19 enfeksiyonunu klinik belirtiler göstermeden ya da hafif bulgularla atlatmış veya influenza olarak yanlış teşhis edilmiş çok sayıda geçmiş vakayı tespit edebiliriz. O zaman antikor test istatistiklerini, salgın tüm dünyayı kasıp kavuruyorken Türkiye’de 11 Mart’a kadar vaka görülmediğinde ısrar eden sağlık otoritelerinin verileriyle karşılaştırabiliriz.

http://www.agos.com.tr/tr/yazi/23859/gercegin-izini-surmek-icin-koronavirus-antikor-testi
Yeni Koronavirüs (2019-nCoV) salgını hayvanlardan insanlara “sıçrayan” ne ilk mikrop, ne de sonuncu olacak. Biz hayvanları yemeye ve doğal yaşam alanlarını işgal etmeye devam ettikçe, benzer salgınlar gerçekleşecektir. Hayvanlardan... more
Yeni Koronavirüs (2019-nCoV) salgını hayvanlardan insanlara “sıçrayan” ne ilk mikrop, ne de sonuncu olacak. Biz hayvanları yemeye ve doğal yaşam alanlarını işgal etmeye devam ettikçe, benzer salgınlar gerçekleşecektir. Hayvanlardan kaynaklanan bu tür salgınları azaltmanın iyi bir yolu da veganlık, vahşi yaşam ticaretini ve insanların hayvansal gıda tüketimini durdurmak ve daha da önemlisi, “hayvan duyarlılığı”nı kabul etmektir.

http://www.agos.com.tr/tr/yazi/23572/koronavirus-salginindan-dersler
Kanada, küresel demokrasi ve barış süreçlerine ciddi katkı yapan ülkelerden. Kanada vatandaşlarının, Kaz Dağları'ndaki doğa katliamına seyirci kalmamaları gerekiyor.
Yapay zekâ (YZ), doktor ofislerinde tanı ve tedavi, sokakta ise yüz tanıma programlarına uyarlanmaya başladı. Ancak YZ robotları sadece bizim algoritmalarına eklediğimiz veriler kadar ‘akıllı’ ve demokratik olabilirler. YZ, görünürdeki... more
Yapay zekâ (YZ), doktor ofislerinde tanı ve tedavi, sokakta ise yüz tanıma programlarına uyarlanmaya başladı. Ancak YZ robotları sadece bizim algoritmalarına eklediğimiz veriler kadar ‘akıllı’ ve demokratik olabilirler. YZ, görünürdeki verilerin arkaplanında gizli tarihsel ve sosyal adaletsizlikleri yaygınlaştırabilir de. Robot etiği söz konusu olduğunda, YZ ve algoritmalarını tasarlayan ve sağlık ile toplum hayatında kullananların uzaylılar değil, tüm önyargılarımızla biz insanlar olduğumuzu unutmamalıyız.
Popülizm ve post-gerçeğin yükselişi insanlığı ve moderniteyi uyanışa çağırıyor: Bilgi üretimi ve gazeteciliğin (ve hayatın kendisinin) değer yargılarıyla dolu, dolayısıyla özünde siyasi olduğunu kabullenmemiz gerek. Gazetecilik ve... more
Popülizm ve post-gerçeğin yükselişi insanlığı ve moderniteyi uyanışa çağırıyor: Bilgi üretimi ve gazeteciliğin (ve hayatın kendisinin) değer yargılarıyla dolu, dolayısıyla özünde siyasi olduğunu kabullenmemiz gerek. Gazetecilik ve aktivizm arasındaki ilişkiyi gözden geçirmeliyiz. 21. Yüzyılda gazeteciliği, demokrasiyi ve dünya barışını tehdit eden şeyin siyaset değil, siyaseti yok sayma ve kontrolsüz insan gücü olduğunu ayırt etmeliyiz.

http://www.agos.com.tr/tr/yazi/21770/ana-akim-gazetecilik-aktivizm-ve-duvardaki-sinek
Umut, demokrasiyi ve azınlık haklarını yönlendiren ve biçimlendiren temel bir öğe olarak çoğu zaman unutulur. Umut yoksunluğu, atalet ve depresyon ağır basar; etkili direnişi veya demokrasi ve insan hakları tartışmalarına katılımı... more
Umut, demokrasiyi ve azınlık haklarını yönlendiren ve biçimlendiren temel bir öğe olarak çoğu zaman unutulur. Umut yoksunluğu, atalet ve depresyon ağır basar; etkili direnişi veya demokrasi ve insan hakları tartışmalarına katılımı engeller. Umudun anlam(lar)ını kavramak bu yüzden, otoriter küresel liderler, baskıcı yönetim ve dünya çapında özgürlükçü demokrasileri tehdit eden realpolitik salgını çağında elzemdir.

Sert güç ile post-truth (hakikat sonrası; post-gerçek) bilimin, yumuşak güç ve gerçeğin yerini aldığı; çok kutuplu küresel politikaların, sürekli bir ekonomik ve politik kriz ile reelpolitiğin belirleyici olduğu yeni bir dünya düzeninde yaşıyoruz. Bu dipsiz kriz zamanlarının tetiklediği iki zihin yapısı var: Umut ve tereddüt. Bu ikiz duygular bugün ölümcül hastalıklardan aile kurmaya veya yeni bir işe başlamaya değin yaşamın her anında ve toplumun her alanında varlığını hissettiriyor.

Fakat umut tam olarak nedir? “Kendini iyi hisset” iyimserliğinden farklı olarak, daha derin bir inanç mıdır? İçinde bulunduğumuz çok kutuplu, otoriteryen ve her türlü duruma ve biçime reelpolitik ile uyum sağlayan akışkan dünyada, karşı karşıya kaldığımız korkutucu sonuçlardan bağımsız olarak umut sürdürülebilir mi?

Sosyolog Zygmunt Bauman (1925-2017) ‘akışkan modernite’ kavramını bir zamanlar modern demokratik toplumları sürdüren sağlam temellerin kayboluşuna işaret etmek için kullanıyordu. Bauman’ın yirmiden fazla yıl önce ortaya koyduğu öngörüleri, günümüzün çok kutuplu dünyasında sürekli krizler, hareketlilik, değişen kimlikler ve aidiyetler aracılığıyla deneyimlenen istikrarsızlığı ve belirsizliği çok iyi yakalamıştır.

http://www.agos.com.tr/tr/yazi/21194/kuresel-populizm-ve-reelpolitik-zamanlarinda-umutnedir